• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Increasing survival rates for patients with acute liver failure

byJeffrey CampbellandSai Folmsbee
April 5, 2016
in Chronic Disease, Gastroenterology, Surgery
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. In this observational cohort study, the rates of 21-day survival for patients with acute liver failure have gradually increased since 1998.

2. During this time period, the causes of acute liver failure and the demographics of patients presenting with this condition have remained relatively constant.

Evidence Rating Level: 2 (Good)

Study Rundown: Acute liver failure (ALF) is a dangerous condition most commonly caused by acetaminophen overdose, affecting approximately 2000 Americans each year. Treatment typically consists of intensive supportive care, and patients may require urgent liver transplantation. Between 1998 and 2013, this study enrolled patients at several major American medical centers who presented with acute liver failure in order to track changes in patient characteristics, causes of ALF, and survival. Overall, during this time period, 21-day survival after study enrollment improved gradually but significantly. Meanwhile, use of intensive therapies, such as blood transfusions, breathing support, and medications to boost blood pressure have decreased, as did the proportion of patients with ALF listed for transplant. There were no major changes in the primary causes or severity of ALF, nor in the demographic characteristics of patients presenting with the condition. This study was limited in that it only enrolled patients from select academic medical centers, and its results may not fully reflect changes in patient characteristics or survival among patients who did not receive treatment at these or similar medical centers; in particular, these data may not reflect the experience of treating ALF at smaller, community hospitals. Furthermore, the study was not designed to identify what caused the identified changes in outcomes. Nonetheless, these results suggest improvements in outcomes for patients presenting with ALF and highlight the need for further research on which specific changes in care led to these improvements.

Click to read the study published today in the Annals of Internal Medicine

Relevant Reading: Intensive care of patients with acute liver failure: recommendations of the US Acute Liver Failure Study Group

RELATED REPORTS

Mirum: Ctexli reduces cholesterol metabolite build-up in patients with cerebrotendinous xanthomatosis

Aligos Therapeutics: ALG-055009 reduces liver fatty deposits in patients with metabolic-dysfunction associated steatohepatitis (MASH)

Liver transplantation plus chemotherapy improves survival in patients with unresectable colorectal liver metastases

In-Depth [observational cohort study]: This study enrolled 2070 consecutive participants between 1998 and 2013 at academic medical centers participating in the Acute Liver Failure Study Group. To be enrolled, patients must have demonstrated coagulopathy and hepatic encephalopathy; patients who received a liver transplant that subsequently failed were excluded from analysis. Participants who were enrolled during the first eight years of the study had significantly lower 21-day survival than did participants who were enrolled during the second eight years of the study (67.1% vs. 75.3%, respectively; p < 0.001). Likewise, transplant-free survival significantly increased between the first and second eight-year periods (45.1% vs. 56.2%, respectively; p < 0.001). The proportion of patients receiving vasopressor support, ventilator support, red blood cell or frozen plasma transfusion, and intracranial monitoring significantly decreased over the study period, as did the proportion of patients listed for transplant. Notably, use of N-acetylcysteine for patients presenting with ALF not due to acetaminophen toxicity increased significantly between the first eight years and the second eight years of the study (15.8% vs. 49.4%, respectively; p < 0.001).

Image: CC/Wiki

©2016 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: liver diseaseliver transplant
Previous Post

Estradiol may be anti-atherosclerotic in early postmenopausal women: the ELITE study

Next Post

Parathyroidectomy associated with increased bone mineral density and decreased fracture rate in patients with primary hyperparathyroidism

RelatedReports

CT texture analysis may predict liver insufficiency after hepatectomy
Pharma

Mirum: Ctexli reduces cholesterol metabolite build-up in patients with cerebrotendinous xanthomatosis

April 15, 2025
Low free sugar diet reduces hepatic steatosis in nonalcoholic fatty liver disease in adolescent males
Pharma

Aligos Therapeutics: ALG-055009 reduces liver fatty deposits in patients with metabolic-dysfunction associated steatohepatitis (MASH)

October 18, 2024
Resection of colorectal liver metastases may improve cost and longevity
Chronic Disease

Liver transplantation plus chemotherapy improves survival in patients with unresectable colorectal liver metastases

October 8, 2024
#VisualAbstract: Aspirin reduces hepatic fat quantity in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) without Cirrhosis
StudyGraphics

#VisualAbstract: Aspirin reduces hepatic fat quantity in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) without Cirrhosis

April 5, 2024
Next Post
Vitamin D supplementation amongst post-menopausal women did not improve functional outcomes

Parathyroidectomy associated with increased bone mineral density and decreased fracture rate in patients with primary hyperparathyroidism

Clinician factors associated with increased PSA screening amongst veterans with limited life expectancy

Higher parental monitoring linked to safer sex in teens

Comparative efficacy and tolerability of evolocumab and ezetimibe in patients with statin intolerance

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • 2 Minute Medicine Rewind July 7, 2025
  • Fecal calprotectin is a useful marker for defining small bowel endoscopic remission in Crohn’s disease
  • Body mass index-specific waist circumference thresholds may improve mortality risk stratification in women
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.