• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Pulmonology

Leukotriene-receptor antagonists associated with reduced risk of asthma exacerbations

byJeffrey CampbellandSai Folmsbee
September 22, 2015
in Pulmonology
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. From a systematic review, the use of leukotriene receptor antagonists (LTRAs) as monotherapy was associated with a decreased risk of asthma exacerbations when compared to placebo.

2. Use of LTRAs in combination with inhaled corticosteroids may have also reduced risk of asthma exacerbation and improved lung function when compared to placebo, although results were mixed.

Evidence Rating Level: 1 (Excellent)

Study Rundown: Asthma affects approximately 300 million people worldwide. Long-term control of asthma is directed at reducing the inflammatory processes that underlie the disease. Leukotriene-receptor antagonists (LTRAs) target these inflammatory processes, and have a number of potential advantages compared to steroids. This study summarized and analyzed several trials comparing LTRAs versus placebo and LTRAs in combination with steroids. When used alone, LTRAs significantly reduced the risk of asthma exacerbations and improved lung function when compared to placebo. When combined with steroids, use of LTRAs was associated with improvement in lung function by some measures, although not with decreased risk of asthma exacerbations. Notably, LTRAs were not associated with increased risk of adverse effects compared to placebo. This study analyzed a diverse set of trials, and was limited by the varied set of outcome measures and treatments used in these trials; this particularly hampered the study from assessing the effect of asthma severity on outcomes. Nevertheless, these results suggest that LTRAs may be effective alternatives to steroids as therapy designed to prevent asthma exacerbations, and that these drugs may also be valuable as add-on therapy for patients already taking steroids.

Click to read the study published today in the Annals of Internal Medicine

Relevant Reading: Guidelines for the Diagnosis and Management of Asthma (EPR-3)

RELATED REPORTS

Depemokimab therapy reduces exacerbations in patients with severe eosinophilic asthma

Different single inhaler triple therapies appear to have similar clinical outcomes for chronic obstructive pulmonary disease

Asthma may be associated with impaired memory function in children

In-Depth [systematic review and meta-analysis]: This systematic review and meta-analysis synthesized results from 50 studies that compared LTRAs (i.e., montelukast, zafirlukast or pranlukast) or LTRAs plus inhaled corticosteroids (ICS) with placebo. As monotherapy, LTRAs were associated with a significantly reduced risk of asthma exacerbation (RR compared to placebo 0.60, 95%CI 0.44-0.81), as well as with significantly improved FEV1 compared to baseline FEV1. When used as add-on therapy with ICS, LTRAs did not significantly reduce the risk of asthma exacerbation compared with placebo (RR 0.80, 95%CI 0.60-1.07); as add-on therapy, they did significantly improve FEV1 over baseline when change in FEV1 was expressed in liters, but not when expressed as percent change. Notably, LTRAs significantly reduced the need for short-acting beta agonists in the included trials, both when used as monotherapy and when used as add-on therapy with ICS. Due to heterogeneity of inclusion criteria, study therapies and outcome measures, only a few studies could be analyzed for each of this trial’s outcomes of interest.

Image: PD

©2015 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

 

Tags: asthma
Previous Post

2 Minute Medicine Rewind September 14 – 20, 2015

Next Post

Pioneer Accountable Care Organization associated with reduced costs on low-value medical services

RelatedReports

Teen asthma controller medication adherence affected by risk tolerance
Chronic Disease

Depemokimab therapy reduces exacerbations in patients with severe eosinophilic asthma

March 4, 2025
2 Minute Medicine Rewind May 20, 2019
Chronic Disease

Different single inhaler triple therapies appear to have similar clinical outcomes for chronic obstructive pulmonary disease

January 7, 2025
Chronic Disease

Asthma may be associated with impaired memory function in children

November 21, 2024
Combined immunotherapy may improve survival in metastatic pancreatic cancer
Pharma

GSK: Depemokimab Monoclonal Antibody Reduces Asthma Attacks

September 16, 2024
Next Post
Corticosteroids improve outcomes in treatment of community-acquired pneumonia

Pioneer Accountable Care Organization associated with reduced costs on low-value medical services

Adverse pregnancy outcomes associated with thrombophilias [Classics Series]

Delayed antimicrobial therapy linked with higher mortality in septic shock [Classics Series]

High fish consumption may reduce depression risk

High fish consumption may reduce depression risk

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Time-restricted eating does not confer changes in sleep, mood, or quality of life
  • Commonly cited medication triggers may not increase risk of microscopic colitis among older adults
  • Ablation may reduce stroke risk, death, heart failure hospitalization in patients with atrial fibrillation
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.