• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home Uncategorized

Long-term use of NSAIDs and aspirin linked to lower risk of colorectal cancer

byKenan Celtik, MSandSai Folmsbee
August 25, 2015
in Uncategorized
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. From a case-control study, using nonsteroidal anti-inflammatory drugs (NSAIDs) or low-dose aspirin continuously for over 5 years was associated with lower risk of colorectal cancer.

2. Rectal cancer, compared to that found in the proximal or distal colon, was associated with the greatest reduction in risk after long-term, high-intensity NSAID use.

Evidence Rating Level: 3 (Average)

Study Rundown: Multiple epidemiologic studies have supported the association between long-term aspirin use and reduced colorectal cancer risk, though it is unclear whether this benefit pertains to all nonsteroidal anti-inflammatory drugs (NSAIDs). This case-control study used the drug use registry in Denmark to determine whether aspirin and other NSAID use was linked to lowering risk of colorectal cancer (CRC). Continuous long-term (≥5 years) low-dose aspirin or NSAID use, having greater than 2 NSAID prescriptions filled prior to CRC diagnosis, or any duration use of >0.1 g daily dose of a NSAID was associated with reduced CRC risk. Rectal cancer, compared to that found in the proximal or distal colon, was associated with the greatest reduction in risk after long-term, high-intensity (>0.3 g daily dose) NSAID use. When broken down by anatomic location, aspirin use of any dosage or duration was not associated with statistically significant CRC risk. Interestingly, COX-2 selective NSAIDs, compared to nonselective NANSAIDs, were associated with a slightly greater CRC risk reduction. Limitations of this study relate to the study design, as only association, but not causality, can be inferred from these results. Overall, this study adds more evidence supporting the role of long-term aspirin and other NSAIDs in decreasing CRC risk.

Click to read the study, published today in the Annals of Internal Medicine

Relevant Reading: A Randomized Trial of Aspirin to Prevent Colorectal Adenomas in Patients with Previous Colorectal Cancer

RELATED REPORTS

Artificial intelligence based clinical decision systems are safe and effective for diabetes management

Epic Launchpad propels generative-AI into everyday hospital routines

#VisualAbstract: Routine Cerebral Embolic Protection Did Not Reduce Stroke Incidence during Transcatheter Aortic-Valve Implantation

In-Depth [case-control study]: This study compared 10,280 known cases of CRC to 102,800 matched control participants without CRC. Cases and controls were demographically similar in every characteristic, except cases were more likely to not have had a colonoscopy (4.5% v. 7.5%). Aspirin was only linked to reduced risk of CRC if used continuously for ≥5 years (OR 0.73, 95%CI 0.54-0.99). However, non-aspirin NSAIDs were associated with reduced CRC risk if they were ever used prior to diagnosis (OR 0.94, 95%CI 0.90-0.98), used at a daily dose between 0.1-0.3 g (OR 0.89, 95%CI 0.81-0.98), used at a daily dose >0.3 g (OR 0.70, 95%CI 0.62-0.78), used for 5 to 10 years (OR 0.89, 95%CI 0.83-0.94), used for >10 years (OR 0.90, 95%CI 0.83-0.98) or used continuously for ≥5 years (OR 0.64, 95%CI 0.52-0.80). When analyzed based on anatomic regions, ≥5 years of high-dose non-aspirin NSAID use was associated with a 38% reduced risk of CRC in the rectum, 31% in the distal colon and 20% in the proximal colon.

Image: CC/Wiki

©2015 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Previous Post

Epidural corticosteroid injections provide only short-term radiculopathy pain relief

Next Post

2 Minute Medicine Rewind August 16 – 23, 2015

RelatedReports

Pediatric DKA associated with recent acute care visits
Chronic Disease

Artificial intelligence based clinical decision systems are safe and effective for diabetes management

July 3, 2025
FDA-regulated clinical trials rarely report violations
AI Roundup

Epic Launchpad propels generative-AI into everyday hospital routines

July 3, 2025
#VisualAbstract: Routine Cerebral Embolic Protection Did Not Reduce Stroke Incidence during Transcatheter Aortic-Valve Implantation
All Specialties

#VisualAbstract: Routine Cerebral Embolic Protection Did Not Reduce Stroke Incidence during Transcatheter Aortic-Valve Implantation

July 3, 2025
Low free sugar diet reduces hepatic steatosis in nonalcoholic fatty liver disease in adolescent males
Chronic Disease

Sodium-glucose cotransporter 2 inhibitors may decrease risk of serious liver events in patients with cirrhosis

July 2, 2025
Next Post
Preoperative bilateral breast imaging may reduce contralateral cancer recurrence

2 Minute Medicine Rewind August 16 – 23, 2015

Insulin costs rose exponentially, regardless of formulation or patent

Insulin costs rose exponentially, regardless of formulation or patent

No significant increased risk of bladder cancer with pioglitazone use

Discontinuation of antihypertensives may not improve cognitive function in elderly [DANTE study]

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Artificial intelligence based clinical decision systems are safe and effective for diabetes management
  • Epic Launchpad propels generative-AI into everyday hospital routines
  • #VisualAbstract: Routine Cerebral Embolic Protection Did Not Reduce Stroke Incidence during Transcatheter Aortic-Valve Implantation
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.