• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Patients with psoriasis associated with increased systemic arterial and subcutaneous adipose inflammation

byRishi ChopraandDavid Wang
January 2, 2017
in Chronic Disease, Dermatology, Imaging and Intervention
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. In a retrospective cohort study of 12 patients with psoriasis, 8F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) demonstrated significantly increased arterial inflammation and subcutaneous adipose tissue inflammation compared to healthy controls.

Evidence Rating Level: 3 (Average)

Study Rundown: Psoriasis is a chronic, inflammatory skin disorder associated with an increased risk for coronary artery disease, likely resulting from a systemic pro-inflammatory state. In addition, previous studies demonstrate that subcutaneous adipose tissue inflammation, which may contribute to the pathogenesis of psoriasis, is also associated with an increased risk of cardiovascular disease. Given the multiple associations demonstrated between psoriasis, inflammation, and atherosclerotic disease, the objective of this study was to assess the relationship between global vascular inflammation and subcutaneous adipose tissue inflammation in patients with moderate-to-severe psoriasis.

The study retrospectively compared vascular and subcutaneous adipose tissue inflammation, as assessed by FDG-PET/CT in 12 patients with moderate-to-severe psoriasis and 24 matched controls without psoriasis. At the conclusion of the study, psoriasis was demonstrated to be associated with significantly increased aortic and subcutaneous adipose inflammation. The results of this study further corroborate that there may be a link between psoriasis skin inflammation, vascular inflammation, cardiovascular disease, and obesity. This study is strengthened by the use of controls matched for age and sex, as well as requiring adequate medication washout periods. However, this study is limited by the small sample size that was selected from a single dermatology clinic. Furthermore, the matched control group consisted of patients with stage 1 penile cancer or localized melanoma that had required FDG-PET/CT imaging, so was not ideal as controls for comparison purposes. There is limited generalizability to the results as mostly men were included in the study and the age of patients ranged from 50 to 70 years old. Larger, multi-center prospective trials may improve the validity of the study.

Click to read the study in BJD

Relevant Reading: Increased Prevalence of Coronary Artery Disease in Severe Psoriasis and Severe Atopic Dermatitis

In-Depth [retrospective cohort]: This study retrospectively evaluated the association between psoriasis and inflammation of the aorta and subcutaneous adipose tissue via an open-label, observational, controlled study of consecutive patients in a university hospital dermatology clinic in Finland. Overall, this study identified 12 patients with psoriasis and 24 controls without psoriasis matched for age and sex. All patients underwent whole-body FDG-PET/CT, and inflammation was measured using maximal standardized uptake values (SUVmax) and the target-to-background ratio (TBRmax). At the conclusion of the trial, in the psoriasis group, arterial inflammation was increased compared with controls (mean whole vessel TBRmax 2.46 vs. 2.09; p = 0.005). Subcutaneous adipose tissue FDG uptake was also increased compared with controls (mean TBRmax 0.49 vs. 0.31; p = 0.002). An analysis of covariance regression model adjusted for body mass index and age confirmed that patients with psoriasis remained significantly associated with elevated whole-vessel TBRmax values.

RELATED REPORTS

Bimekizumab is effective for active psoriatic arthritis in biologic-naĂŻve adults

CT associated with lower complication risks than invasive coronary angiography

#VisualAbstract: IL-17 inhibitors are associated with higher treatment persistence than TNF inhibitors in patients with psoriasis and psoriatic arthritis

Image: CC/Wiki/James Heilman, MD

©2016 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: Computed Tomography (CT)Positron Emission Tomography (PET Scan)psoriasis
Previous Post

Protein therapy combined with stem cell transplantation repairs stroke-induced brain damage [PreClinical]

Next Post

2 Minute Medicine Rewind January 2, 2017

RelatedReports

Long-term use of apremilast for psoriasis associated with an acceptable safety profile
Chronic Disease

Bimekizumab is effective for active psoriatic arthritis in biologic-naĂŻve adults

January 24, 2023
PCI not superior to medical therapy alone in stable coronary disease: The COURAGE study
Cardiology

CT associated with lower complication risks than invasive coronary angiography

May 13, 2022
#VisualAbstract: IL-17 inhibitors are associated with higher treatment persistence than TNF inhibitors in patients with psoriasis and psoriatic arthritis
StudyGraphics

#VisualAbstract: IL-17 inhibitors are associated with higher treatment persistence than TNF inhibitors in patients with psoriasis and psoriatic arthritis

April 7, 2022
Patient Basics: Atherosclerosis
Cardiology

Computed tomography a suitable diagnostic alternative for obstructive coronary artery disease

March 14, 2022
Next Post
Cognitive outcomes in older adults undergoing cardiovascular procedures unclear

2 Minute Medicine Rewind January 2, 2017

AAP supports mindfulness of children’s media consumption

22% of U.S. gun owners report purchasing a firearm without a background check

Publication of pneumonia antibiotic guidelines changed prescribing trends

Metformin associated with reduced mortality in kidney disease, congestive heart failure, and chronic liver disease

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Rocatinlimab may be effective in the treatment of moderate-to-severe atopic dermatitis
  • Gender-affirming hormones improve psychosocial functioning in transgender youth
  • Left atrial reservoir strain improves ischemic stroke risk prediction in low-risk patients
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options