• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Peanut allergy effectively treated with oral immunotherapy: the PALISADE trial

byDayton McMillan
November 22, 2018
in Chronic Disease, Pediatrics, Public Health
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. After 24 weeks of oral immunotherapy treatment, patients with peanut allergy were able to consume significantly more peanut protein without allergic symptoms compared to patients treated with a placebo.

2. Treatment was shown efficacious is patients aged 4 to 17 and not efficacious in patients over 18 years of age.

Evidence Rating Level: 1 (Excellent)      

Study Rundown: Peanut allergy is prevalent in many industrialized countries and is becoming more common. This allergy can be life threatening and can persist throughout a patient’s lifetime. Current treatment options include avoidance, desensitization, and rescue medication utilization. A new orally available immunotherapy consisting of peanut protein, AR101, may provide a clinically useful method for treating patients with peanut allergy. The randomized Peanut Allergy Oral Immunotherapy Study of AR101 for Desensitization (PALISADE) trial evaluated patients with a low-threshold sensitivity to peanut protein and tested them again after 24 weeks of treatment with a higher peanut protein dose. For patients aged 4 to 17, those treated had significantly fewer allergic responses compared to those treated with placebo at the end of the trial. Therapy was not shown to be effective for patients over 18 years of age.

Strengths of this study include its randomized controlled design and its evaluation of a first-in-class treatment. Limitations include its limited inclusion of patients over 18 years of age and lack of statistical comparison of adverse events between the treatment and placebo groups.

Click to read the study, published today in NEJM

Relevant Reading: Effect of avoidance on peanut allergy after early peanut consumption

RELATED REPORTS

#VisualAbstract: Neoadjuvant nivolumab plus chemotherapy increases event-free survival in resectable non-small-cell lung cancer

#VisualAbstract: Peanut oral immunotherapy desensitizes young children with non-anaphylactic peanut allergies

Peanut oral immunotherapy desensitizes young children with non-anaphylactic peanut allergies

In-Depth [randomized controlled trial]: This multicenter, international, randomized controlled trial enrolled patients aged 4 to 55 who had a history of peanut allergy and positive peanut specific IgE levels. All patients had allergic reactions to a screening dose of 100 mg peanut protein. Patients were randomized in a 3:1 manner to receive AR101, a peanut-based biologic, or a placebo. Doses of treatment were escalated initially, then patients received 24 weeks of a maintenance phase consisting of 300 mg AR101 or a matching placebo. Following the maintenance phase, an exit-food challenge consisted of 300, 600, and 1000 mg peanut protein (as tolerated) to assess for peanut protein allergic response. A total of 551 patients received AR101 or placebo, and 55 patients were 18 years or older. Most patients had a history of asthma, peanut anaphylaxis, or multiple food allergies. At initial screening, the median tolerated dose of peanut protein was 10 mg. Of patients aged 4 to 17, 67.2% (250/372) of the treated patients were able to ingest 600 mg of peanut protein without dose-limiting symptoms at the exit-challenge compared to 4.0% (5/124) of those in the placebo group (between group difference of 63.2 percentage points; 95% confidence interval [CI], 53.0 to 73.3; P<0.001). Patients tolerated 1000 mg of peanut protein at rates of 50.3% vs 2.4% in the treatment and placebo groups, respectively. Severe allergic symptoms were elicited in 5% and 11% of the treatment and placebo groups, respectively, during the exit challenge (P<0.001). For patients aged 18 or older 41.5% and 14.3% of treatment and placebo patients tolerated 600 mg of peanut protein, which was not statistically significant. During the study, not including the exit challenge, 4.3% and 0.8% of patients experienced severe allergic symptoms.

Image: PD

©2018 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: allergyimmunotherapy
Previous Post

Omalizumab (XOLAIR®) could be a new rescue option for asthma

Next Post

Improved survival with open surgery compared to minimally invasive radical hysterectomy among early cervical cancer patients

RelatedReports

#VisualAbstract: Neoadjuvant nivolumab plus chemotherapy increases event-free survival in resectable non-small-cell lung cancer
StudyGraphics

#VisualAbstract: Neoadjuvant nivolumab plus chemotherapy increases event-free survival in resectable non-small-cell lung cancer

April 28, 2022
#VisualAbstract: Endotracheal intubation offers no benefit over supraglottic airway in patients with out-of-hospital return of spontaneous circulation
StudyGraphics

#VisualAbstract: Peanut oral immunotherapy desensitizes young children with non-anaphylactic peanut allergies

April 13, 2022
Peripregnancy nut consumption may decrease development of nut allergies
Chronic Disease

Peanut oral immunotherapy desensitizes young children with non-anaphylactic peanut allergies

March 1, 2022
#VisualAbstract: Fulvestrant plus cyclin-dependent kinase 4/6 inhibitors improves survival in HR⁺, HER2- metastatic breast cancer
StudyGraphics

#VisualAbstract: Time-of-infusion with immunotherapy may impact survival outcomes for patients with advanced melanoma

February 16, 2022
Next Post
Cervical cancer screening practices less cost-effective than suggested guidelines

Improved survival with open surgery compared to minimally invasive radical hysterectomy among early cervical cancer patients

Survival greater in cervical cancer patients undergoing abdominal hysterectomy compared to minimally invasive techniques: the LACC trial

Survival greater in cervical cancer patients undergoing abdominal hysterectomy compared to minimally invasive techniques: the LACC trial

Radiation plus hormone therapy may improve prostate cancer survival

Quick Take: Surgery vs Radiotherapy in the Management of Biopsy Gleason Score 9-10 Prostate Cancer and the Risk of Mortality

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

Get 2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • #VisualAbstract: Bimekizumab shows a favourable 2-year safety profile in patients with moderate to severe plaque psoriasis
  • Medical cannabis provides little improvement to sleep in chronic pain patients
  • Alzheimer disease in individuals with Down syndrome has similar variability in age of onset and mortality rate as autosomal dominant forms
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.