• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Prone positioning decreases mortality in severe ARDS (PROSEVA Trial)

bys25qthea
May 22, 2013
in Chronic Disease, Infectious Disease, Pulmonology
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

Image: CC/JHeilman

1. ICU patients with severe Acute Respiratory Distress Syndrome (ARDS) who underwent prone positioning had lower 28-day and 90-day mortality rates than those who remained supine. 

2. This mortality benefit appears to stem from superior oxygenation and a decrease in ventilator lung strain that has been shown in prior studies. 

Evidence Rating Level: 1 (Excellent) 

Study Rundown: Prior studies have shown that prone positioning of ventilated patients allows for more homogenous oxygenation and reduced lung strain than supine positioning.  However, no studies had shown a clear mortality benefit to this practice.  The PROSEVA trial found that placing ICU patients with severe acute respiratory distress syndrome (ARDS) in prone position early in the clinical course significantly increased survival rates.  The study was performed at centers that already employed prone-positioning in their ICUs and were therefore well-versed in the practice.  Therefore, the results of the trial might not be generalizable to centers without prior experience.  Additionally, the protocol used by PROSEVA involved returning patients to supine position.  It is possible the observed mortality benefit may stem from the act of turning the patients between prone and supine position and not from being in the prone position itself.

Click to read the study in NEJM

In-Depth [randomized controlled trial]: This trial compared the outcomes of ARDS patients who were treated in traditional supine position with those who were placed in prone position.  3,449 ARDS patients were recruited from a total of 27 ICU’s across France and Spain.  Of these, 466 were randomized and included in follow-up analysis.  229 patients were randomly assigned to the supine group and 237 were assigned to the prone group.  Patients in the prone group had to be placed in the prone position for at least 16 consecutive hours, and had to be turned to the supine position at least once a day. The primary outcome measured was 28-day mortality.  The secondary outcomes included 90-day mortality, rate of successful extubation and length of stay in the ICU.  28-day mortality was significantly lower in the prone group than in the supine group (16% vs. 32.8% p<0.001) as was 90 day mortality (23.6% vs. 41% p<0.001), and the rate of successful extubation (80% vs. 65%, p<0.001).  Length of ICU stay did not differ among the groups.

RELATED REPORTS

Haloperidol does not improve outcomes at 90 days in ICU patients with delirium

#VisualAbstract: Haloperidol provides no additional benefit for the management of delirium in patients admitted to the ICU

Neutrophil CD64 index may be superior for screening for pediatric infections in the ICU

By Akira Shishido and Mitalee Patil

More from this author: Pneumocystis linked to sudden infant deaths, Continuous infusion of beta-lactams may be superior to bolus therapy, Novel antiviral drug reduces influenza viral load, Three months of antibiotics appear to effectively treat early-onset spinal implant infections, [Physician Comment] Recurrent early Lyme disease is caused by reinfection, not relapse, Hospital Acquired MRSA pays no attention to vancomycin effectiveness, Oseltamivir treats avian flu early,

© 2013 2minutemedicine.com. All rights reserved. No works may be reproduced without written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post should be construed as medical advice and is not intended as such by the authors or by 2minutemedicine.com. PLEASE SEE A HEALTHCARE PROVIDER IN YOUR AREA IF YOU SEEK MEDICAL ADVICE OF ANY SORT. Content is produced in accordance with fair use copyrights solely and strictly for the purpose of teaching, news and criticism. No benefit, monetary or otherwise, is realized by any participants or the owner of this domain. 

Tags: Acute Respiratory Distress SyndromeARDSICUPROSEVA
Previous Post

Antidepressant may reduce mental stress-induced myocardial ischemia (REMIT Trial)

Next Post

Acellular Pertussis vaccine less effective than whole-cell vaccine

RelatedReports

2 Minute Medicine Rewind October 14, 2019
Emergency

Haloperidol does not improve outcomes at 90 days in ICU patients with delirium

January 8, 2023
#VisualAbstract: Haloperidol provides no additional benefit for the management of delirium in patients admitted to the ICU
StudyGraphics

#VisualAbstract: Haloperidol provides no additional benefit for the management of delirium in patients admitted to the ICU

January 3, 2023
Emergency

Neutrophil CD64 index may be superior for screening for pediatric infections in the ICU

December 20, 2022
#VisualAbstract: Early mobilization after ICU mechanical ventilation does not improve survival
StudyGraphics

#VisualAbstract: Early mobilization after ICU mechanical ventilation does not improve survival

December 1, 2022
Next Post
Immunotherapy shows efficacy for pediatric allergic asthma and rhinitis

Acellular Pertussis vaccine less effective than whole-cell vaccine

Early risk factor for progression of cystic fibrosis identified

Early risk factor for progression of cystic fibrosis identified

Childhood ADHD associated with increased risk of suicide [Physician Comment]

Artificial neural networks predict survival in brain metastasis patients

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • The Scan by 2 Minute Medicine®: Maternity Leave Left Out, Dry January, A Measles Resurgence, Dr. GPT
  • Former professional football players may be at greater risk of chronic disease
  • Low-dose pirfenidone may be noninferior to standard dosing in patients with idiopathic pulmonary fibrosis
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options