• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Early risk factor for progression of cystic fibrosis identified

bys25qthea
May 22, 2013
in Chronic Disease, Infectious Disease, Pediatrics, Pulmonology
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

Image: PD

1. Neutrophil elastase activity in bronchoalveolar lavage fluid at 3 months is a risk factor for persistent bronchiectasis at 12 months and 3 years of age.  

Study Rundown: Bronchiectasis, the abnormal dilation of parts of the bronchial tree, is a clinically significant consequence of cystic fibrosis (CF). In children with CF, bronchiectasis may develop within the first few years of life, and once present, tends to progress despite the best medical efforts.

In this study, the authors identify biomarkers in bronchoalveolar lavage (BAL) fluid that are associated with development of bronchiectasis. In particular, they found that the presence of neutrophil elastase activity in the BAL fluid at 3 months of age was a risk factor for persistent bronchiectasis at 12 months and 3 years of age. They did not correlate the degree of elastase activity with the degree of increased risk.

Therapies targeting neutrophil elastase are in development, and the authors suggest that neutrophil elastase activity in BAL fluid could be used to select high-risk infants for clinical trials. Otherwise, it remains to be seen whether this risk factor will find clinical relevance. In the absence of an effective intervention, there is, for now, no clear indication to screen for this risk factor.

Click to read the study in the New England Journal of Medicine

RELATED REPORTS

Nerandomilast slows decline in FVC in idiopathic pulmonary fibrosis

Nerandomilast slows FVC decline in progressive pulmonary fibrosis

Tumor-infiltrating clonal hematopoiesis is associated with NSCLC recurrence

Relevant Reading: Bronchiectasis in infants and preschool children diagnosed with cystic fibrosis after newborn screening

In-Depth [longitudinal study]: Data from 127 infants enrolled in the AREST CF surveillance program were used in the study. CT scans and BAL were performed under general anesthesia at 3 months, 1 year, 2 years and 3 years of age. BAL fluid was analyzed for signs of infection and inflammation, including bacterial cultures, inflammatory cell counts and free neutrophil elastase activity. CT scans were scored for bronchiectasis and gas trapping by blinded assessors. The data was analyzed to look for associations between the biomarkers in the BAL fluid and CT-scored bronchiectasis.

The prevalence of bronchiectasis increased from 29.3% at 3 months of age to 61.5% at 3 years of age (P<0.001). Neutrophil elastase activity was detected in 23.3% of BAL samples at 3 months. This was associated with an odds ratio of 7.2 (95% CI, 2.14 to 24.28; P<0.001) for persistent bronchiectasis at 12 months and an odds ratio of 4.21 (95% CI, 1.45 to 12.21; P=0.008) for persistent bronchiectasis at 3 years of age.

By Tomi Jun and Mitalee Patil

© 2013 2minutemedicine.com. All rights reserved. No works may be reproduced without written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post should be construed as medical advice and is not intended as such by the authors or by 2minutemedicine.com. PLEASE SEE A HEALTHCARE PROVIDER IN YOUR AREA IF YOU SEEK MEDICAL ADVICE OF ANY SORT. Content is produced in accordance with fair use copyrights solely and strictly for the purpose of teaching, news and criticism. No benefit, monetary or otherwise, is realized by any participants or the owner of this domain. 

Tags: bronchiectasiscystic fibrosishealthpulmonology
Previous Post

Acellular Pertussis vaccine less effective than whole-cell vaccine

Next Post

Artificial neural networks predict survival in brain metastasis patients

RelatedReports

Multiple-electrode switching radiofrequency ablation may successfully treat lung tumors
Pharma

Nerandomilast slows decline in FVC in idiopathic pulmonary fibrosis

July 11, 2025
Pulmonary MRI with ultrashort echo time is comparable to pulmonary CT
Pharma

Nerandomilast slows FVC decline in progressive pulmonary fibrosis

July 8, 2025
Lessons from real-world implementation of lung cancer screening
Oncology

Tumor-infiltrating clonal hematopoiesis is associated with NSCLC recurrence

July 7, 2025
Multiple-electrode switching radiofrequency ablation may successfully treat lung tumors
Cardiology

Sotatercept reduces adverse event risk in high-risk pulmonary arterial hypertension

June 5, 2025
Next Post
Childhood ADHD associated with increased risk of suicide [Physician Comment]

Artificial neural networks predict survival in brain metastasis patients

Adenotonsillectomy improves behavior in childhood obstructive sleep apnea (CHAT Trial)

Adenotonsillectomy improves behavior in childhood obstructive sleep apnea (CHAT Trial)

CT scans linked to cancer risk in children

CT scans linked to cancer risk in children

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • #VisualAbstract: Obicetrapib Reduced LDL Cholesterol in Patients at High Cardiovascular Risk
  • St. Louis hospital-based violence intervention program did not significantly affect reinjury outcomes
  • Glucagon-like peptide-1 receptor agonists may increase risk of reflux in patients with type 2 diabetes
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.