• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Imaging and Intervention

Prostate-Specific Membrane Antigen Positron Emission Tomography can be used to detect pelvic lymph nodes in prostate cancer

byJamie ParkandSze Wah Samuel Chan
October 3, 2021
in Imaging and Intervention, Oncology, Urology
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. For the detection of pelvic nodal metastases in men with intermediate-to high-risk prostate cancer, using the 68Ga-PSMA-11 PET scan, the sensitivity and specificity were 0.40 and 0.95

2. The positive predictive value and the negative predictive value were 0.75 and 0.81

Evidence Rating Level: 1 (Excellent)

Study Rundown: Positron emission tomography (PET) targeting prostate-specific membrane antigen (PSMA) can increase diagnostic accuracy to help better detect pelvic nodal metastases at initial staging. Detecting pelvic nodal metastases at initial staging can guide clinicians when determining the appropriateness of radial prostatectomy. This study aimed to evaluate the accuracy of 68Ga-PSMA-11 PET imaging to detect pelvic nodal metastases compared to histopathology in intermediate- to high-risk prostate cancer patients being considered for radical prostatectomy. 68Ga-PSMA-11 PET imaging had lower sensitivity compared to the predefined threshold but had high specificity. The positive predictive value (PPV) was high at 0.75 and the negative predictive value (NPV) was 0.81. One of the main limitations include having lower number of the study population included in the efficacy analysis due to patients receiving other therapies instead of prostatectomy. This could have contributed to the lower sensitivity rate since patients with more extensive nodes were treated using alternative therapies. Another limitation is the open label study design of the study, which allowed clinicians to modify therapy based on the PET scan results. Overall, this study demonstrated that a positive 68Ga-PSMA-11 PET imaging could be a beneficial tool to help clinicians detect pelvic nodal metastasis as a true positive in intermediate- to high-risk prostate cancer patients considering prostatectomy. However, it may not be reliable in ruling out nodal metastases and may require further studies.

Click to read the study in JAMA Oncology

Click to read an accompanying invited commentary in JAMA Oncology

Relevant Reading: Outcomes of primary lymph node staging of intermediate and high risk prostate cancer with 68Ga-PSMA positron emission tomography/computerized tomography compared to histological correlation of pelvic lymph node pathology

RELATED REPORTS

Plant-based diets may be associated with lower risk of aggressive prostate cancer

Wellness Check: Nutrition

#VisualAbstract: Positive prostate MRI and targeted biopsy reduce the detection of clinically insignificant prostate cancer

In-Depth [prospective cohort]: This was a phase 3, prospective, multicenter, single-arm, open label imaging trial of 764 patients at 2 institutions in the United States. Eligible patients included those who had intermediate- to high-risk prostate cancer and were considered for radical prostatectomy. Patients were excluded if they received prostate cancer therapy prior to prostatectomy. All patients received an imaging scan with 3-7 mCi of 68Ga-PSMA-11 PET. However, only patients who received radical prostatectomy were included in the efficacy analysis. The primary endpoint was the sensitivity and specificity of the 68Ga-PSMA-11 PET to detect pelvic nodal metastases compared to histopathology. Each imaging scan of the patients who were included in the efficacy analysis was interpreted by 3 blinded, independent central readers that were not involved in the study design and data collection process. The sensitivity and specificity were 0.40 (95% confidence interval [CI]: 0.34-0.46) and 0.95 (95% CI: 0.92-0.97). The positive predictive value (PPV) and the negative predictive value (NPV) were 0.75 (95% CI: 0.92-0.97) and 0.81 (95% CI: 0.76-0.85. Grade 1 adverse events were reported in 6% of the patients and none required further intervention. Commonly reported adverse events were rash and nausea.

Image: PD

©2021 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: PET scanPositron Emission Tomography (PET Scan)prostate cancer
Previous Post

Non-abstinent recovery may be possible for those with Alcohol Use Disorder

Next Post

Adavosertib compared with active monitoring is potentially effective against TP53/RAS-mutant metastatic colorectal cancer.

RelatedReports

Vegetarian diet may lower incidence of colorectal cancer
Lifestyle

Plant-based diets may be associated with lower risk of aggressive prostate cancer

January 27, 2023
Improved glycemic control in type 1 diabetics on very low-carbohydrate diets
Wellness

Wellness Check: Nutrition

January 26, 2023
#VisualAbstract: Positive prostate MRI and targeted biopsy reduce the detection of clinically insignificant prostate cancer
StudyGraphics

#VisualAbstract: Positive prostate MRI and targeted biopsy reduce the detection of clinically insignificant prostate cancer

January 4, 2023
2MM Podcast

The 2 Minute Medicine Podcast Episode 2

November 22, 2022
Next Post
Quick Take: Effect of Pregabalin on Radiotherapy-Related Neuropathic Pain in Patients With Head and Neck Cancer: A Randomized Controlled Trial

Adavosertib compared with active monitoring is potentially effective against TP53/RAS-mutant metastatic colorectal cancer.

Tips to Manage Your Mental Health During the COVID-19 Outbreak

Patients with low back pain or pain at multiple sites at highest risk for chronic opioid use

United States providers increased prescribing of buprenorphine/naloxone

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Low-dose pirfenidone may be noninferior to standard dosing in patients with idiopathic pulmonary fibrosis
  • Protein-truncating variants in apolipoprotein B and PCSK9 genes associated with lower exposure to atherogenic LDL cholesterol and risk of coronary heart disease
  • College campus monkeypox outbreaks can be controlled with timely detection and isolation
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options