• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Quick Take: Induction of Labor at 41 Weeks Versus Expectant Management Until 42 Weeks (INDEX): Multicenter, Randomized Non-Inferiority Trial

byKyle HoffmanandAliya Ramjaun
March 2, 2019
in Chronic Disease, Obstetrics, Pediatrics
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

It has been well established that pregnancy extending beyond 42 weeks is associated with higher rates of perinatal morbidity and mortality. However, there is variability in the current management of pregnancies extending beyond 41 weeks. In this randomized controlled non-inferiority trial, 1801 low-risk women with an uncomplicated singleton pregnancy were randomized to undergo either induction of labor at 41 weeks or expectant management until 42 weeks to compare outcomes in perinatal mortality and neonatal morbidity. A composite score of perinatal mortality and neonatal morbidity, as measured by the presence of any of several pathologies or admission to the Neonatal Intensive Care Unit, was used as the primary outcome. Researchers found that expectant management, with 3.1% of women having adverse perinatal outcomes, was inferior to induction of labor at 41 weeks, with 1.7% of women having adverse outcomes in that group (absolute risk difference -1.4%, 95% CI -2.9% to 0.0%, p=0.22 for non-inferiority). In addition, infants in the induction group were less likely to have an Apgar score less than 7 at 5 minutes when compared to the expectant management group (RR 0.48, 95% CI 0.23 to 0.98). The two treatment arms did not differ in terms of rates of caesarean section or adverse maternal outcomes. This study therefore shows that induction of labor at 41 weeks in low-risk women with an uncomplicated singleton pregnancy is associated with improved perinatal outcomes.

Click to read the study in the BMJ

©2019 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

RELATED REPORTS

Medbridge turns any phone into a motion-capture coach for at-home rehab

Structured exercise intervention improves survival in colon cancer patients

#VisualAbstract: Neoadjuvant and Adjuvant Pembrolizumab in Locally Advanced Head and Neck Cancer

Previous Post

Prolonged antibiotic use in very low birth weight neonates associated with increased morbidity

Next Post

Patient-centered transitional care services unlikely to benefit hospitalized heart failure patients

RelatedReports

Active sexting among teens related to sexual activity
AI Roundup

Medbridge turns any phone into a motion-capture coach for at-home rehab

July 10, 2025
Development of a risk index for colorectal cancer screening
Gastroenterology

Structured exercise intervention improves survival in colon cancer patients

July 9, 2025
#VisualAbstract: Neoadjuvant and Adjuvant Pembrolizumab in Locally Advanced Head and Neck Cancer
StudyGraphics

#VisualAbstract: Neoadjuvant and Adjuvant Pembrolizumab in Locally Advanced Head and Neck Cancer

July 9, 2025
Cerebral protection device effective in patients undergoing transcatheter aortic valve implantation
Cardiology

Cerebral embolic protection does not decrease stroke incidence in TAVI patients

July 8, 2025
Next Post
Hypercortisolemia in ICU patients is due to reduced cortisol metabolism, not increased production

Patient-centered transitional care services unlikely to benefit hospitalized heart failure patients

Physician visual assessment of coronary stenosis severity overestimates quantitative coronary angiography

Coronary CT angiography superior to functional stress testing among diabetic patients

Significant percentage of pediatricians dismiss families who refuse vaccines

Danish study finds no association between MMR vaccine and autism, even within high-risk subgroups

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Medbridge turns any phone into a motion-capture coach for at-home rehab
  • Structured exercise intervention improves survival in colon cancer patients
  • #VisualAbstract: Neoadjuvant and Adjuvant Pembrolizumab in Locally Advanced Head and Neck Cancer
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.