• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Risk-based lung cancer screening may prevent more deaths than current guidelines

byEvelyn NguyenandDeepti Shroff Karhade
January 12, 2018
in Chronic Disease, Imaging and Intervention, Oncology, Public Health, Pulmonology
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. In terms of early lung cancer death per individual screened, targeting lung cancer mortality risk may improve lung cancer screening efficiency.

2. However, the increases in efficiency were attenuated when measured by life-years, quality-adjusted life-years (QALYs), and cost-effectiveness.

Evidence Rating Level: 2 (Good)         

Study Rundown: Current guidelines for lung cancer screening using low-dose computed tomography (LDCT) do not take into consideration long-term survival differences or cost differences between higher- and lower-risk patients.  This cost-effectiveness analysis calculated the value of individualized risk-based criteria for lung cancer screening in comparison to the National Lung Screening Trial (NLST) eligibility criteria.  Using NLST data, researchers stratified 53 086 participants according to their baseline risk for lung cancer mortality.  Using a multistate prediction model, the authors found that targeting risk may improve the efficiency of screening when measured by early lung cancer death per individual screened.  However, the increases in efficiency were attenuated when measured by life-years, QALYs, and cost-effectiveness.  Considering that high-risk patients cost more to screen and have a reduced life expectancy after any lung cancer survival, the authors suggested that using a risk model is not likely to result in considerable improvement in the cost-effectiveness of lung cancer screening using LDCT (as measured by QALYs gained compared to cost).

A strength of this study is that it takes into consideration differences in long-term survival of lung cancer and quantifies the cost differences between higher- and lower-risk patients.  A limitation of this study is that the study design does not take into account all associated differences between the risk of mortality from lung cancer and quality of life.

Click to read the study in Annals of Internal Medicine

Relevant Reading: Targeting of low-dose CT screening according to the risk of lung-cancer death

RELATED REPORTS

#VisualAbstract: Segmentectomy is superior to lobectomy for patients with early-stage non-small cell lung cancer

Segmentectomy is superior to lobectomy for patients with early-stage non-small cell lung cancer

Increases in muscle-strengthening activities may reduce mortality risk and certain diseases

In-Depth [cost-effective analysis]: Using data from the NLST regarding 53 086 participants, researchers stratified the participants into deciles based on their 7-year risk of lung cancer mortality. Researchers used a multistate prediction model to measure several outcomes for LDCT compared to chest radiography for each decile.  The researchers found that participants who had a higher risk of death from lung cancer were older, had more comorbidities, and had increased costs related to screening.  For the first 7 years, 1.2 (lowest risk decile) to 9.5 (highest risk decile) deaths due to lung cancer were prevented per 10 000 person-years.  Across risk groups, the gradient of benefits was lessened when measured in life-years and QALYs, and the incremental cost-effectiveness ratios (ICERs) were comparable.  The ICER was $75 000 per QALY and $53 000 per QALY for the lowest and highest risk deciles, respectively.  Participants willing to spend $100 000 per QALY would obtain LDCT screening for all deciles.

Image: PD

©2018 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

 

Tags: cancer screeninglung cancerscreening guidelines
Previous Post

Live-birth rates similar among ovulating women undergoing fresh- or frozen-embryo transfer

Next Post

Postnatal cytolomegalovirus infection not linked to impaired motor development

RelatedReports

#VisualAbstract: Increased physical activity is a long-term protective factor for dementia
StudyGraphics

#VisualAbstract: Segmentectomy is superior to lobectomy for patients with early-stage non-small cell lung cancer

May 18, 2022
Quick Take: Intravenous patient-controlled analgesia versus thoracic epidural analgesia after open liver surgery
Chronic Disease

Segmentectomy is superior to lobectomy for patients with early-stage non-small cell lung cancer

May 3, 2022
Exercise improves aromatase inhibitor-induced arthralgia in breast cancer survivors
Cardiology

Increases in muscle-strengthening activities may reduce mortality risk and certain diseases

May 3, 2022
Chronic Disease

COVID-19 pandemic associated with reductions in delivery of cancer care services in Ontario, Canada

April 29, 2022
Next Post
Postnatal cytolomegalovirus infection not linked to impaired motor development

Postnatal cytolomegalovirus infection not linked to impaired motor development

Low circulating cholesterol in neonates linked with pyloric stenosis

Broader statin use more likely to prevent cardiovascular events

Infant room-sharing associated with less nighttime sleep and unsafe sleep practices

Urinalysis highly sensitive and specific for UTI in febrile infants

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

Get 2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • #VisualAbstract: Bimekizumab shows a favourable 2-year safety profile in patients with moderate to severe plaque psoriasis
  • Medical cannabis provides little improvement to sleep in chronic pain patients
  • Alzheimer disease in individuals with Down syndrome has similar variability in age of onset and mortality rate as autosomal dominant forms
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.