• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Oncology

Salvage esophagectomy may improve survival in patients with esophageal cancer

byDaniel LeeandChaz Carrier
April 19, 2015
in Oncology, Surgery
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. Extent of resection and preoperative tumor depth were significant predictors of improved 3- and 5-year survival in patients who received salvage esophagectomy for recurrent or residual disease following definitive chemotherapy.

2. Resection with negative margins (R0) was associated with earlier stage of cancer (T1/2) at diagnosis and initial complete response with definitive chemotherapy.

Evidence Rating Level: 2 (Good)

Study Rundown: Salvage esophagectomy is offered to patients with residual or recurrent esophageal cancer after definitive chemotherapy (dCRT). Although salvage esophagectomy is a high-risk surgery associated with high rates of morbidity and mortality, several studies have reported that a subpopulation of patients may have improved outcomes with the surgery. This study sought to identify prognostic factors for patients undergoing salvage esophagectomy after failed definitive chemotherapy. The authors found no in-hospital mortality among patients with early stage disease (cT1/2 without nodal involvement) and those who achieved complete response to dCRT. Additionally, they reported that resection with negative margins (R0) and early tumor stage (T1/T2) after dCRT were significant independent predictors for improved survival among salvage esophagectomy patients. R0 resection was associated with tumor depth prior to surgery, tumor depth before dCRT, dCRT response and resectability before dCRT.  Major strengths of this study were the large cohort of patients it examined over a span of 25 years, and multivariate analysis of cancer stage and dCRT response on patient survival. However, the study is limited by its retrospective nature, the lack of control for co-morbidities and the lack of comparison groups.

Click to read the study in the Annals of Surgical Oncology

Relevant Reading: Salvage Esophagectomy in the Management of Recurrent or Persistent Esophageal Carcinoma

RELATED REPORTS

Active Surveillance vs Standard Surgery Post-Neoadjuvant Chemoradiotherapy for Esophageal Cancer

Perioperative chemotherapy improves survival in esophageal cancer

#VisualAbstract: Perioperative Chemotherapy is Superior to Preoperative Chemoradiotherapy in Esophageal Cancer

In-Depth [retrospective cohort]: A total of 63 patients who underwent salvage esophagectomy between April 1988 and December 2013 were included in the study. All surgeries were performed at the Cancer Institute Hospital in Tokyo, Japan. Demographic information, clinicopathologic features and response to chemotherapy were collected for all patients. Outcome measures included postoperative hospital stays, complications, mortality, and overall survival from the date of esophagectomy to the date of death or to the last known follow-up date. Kaplan-Meier survival analysis was performed. Univariate logistic regression was used to identify predictors for R0 resection. There was no in-hospital mortality among 20 patients with cT1-2 tumors, 24 without nodal involvement prior to dCRT or 20 patients who achieved complete response to dCRT. However, there was no statistical difference in clinicopathologic features between the groups, stratified according to the presence or absence of in-hospital mortality. The 3- and 5-year overall survival of the entire cohort was 29.8% and 15.0%, respectively. R0 resection (HR 0.27; 95%CI 0.115-0.614) and preoperative tumor depth (ypT1/2; HR: 0.34; 95%CI 0.141-0.792) were significant independent predictors for improved survival. In addition, R0 resection was associated with tumor depth before dCRT, tumor depth after dCRT, dCRT response and resectability before dCRT on univariate analyses. However, none remained significant on the multivariate analysis.

Image: PD

©2015 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: esophageal cancersalvage esophagectomy
Previous Post

Forearm parathyroid reimplantation may be effective in preventing hypoparathyroidism

Next Post

Proper immunoprophylaxis lowers Hepatitis B in infants

RelatedReports

Incidence of esophageal cancer subtypes vary drastically globally and by gender
Chronic Disease

Active Surveillance vs Standard Surgery Post-Neoadjuvant Chemoradiotherapy for Esophageal Cancer

March 24, 2025
Hybrid minimally invasive esophagectomy associated with lower complication rates compared to open esophagectomy
Gastroenterology

Perioperative chemotherapy improves survival in esophageal cancer

March 6, 2025
#VisualAbstract: Perioperative Chemotherapy is Superior to Preoperative Chemoradiotherapy in Esophageal Cancer
StudyGraphics

#VisualAbstract: Perioperative Chemotherapy is Superior to Preoperative Chemoradiotherapy in Esophageal Cancer

February 7, 2025
Hybrid minimally invasive esophagectomy associated with lower complication rates compared to open esophagectomy
Chronic Disease

Esophageal candida infection associated with increased esophageal cancer risk in patients with achalasia

January 24, 2025
Next Post

Proper immunoprophylaxis lowers Hepatitis B in infants

Targeted interventions effective in teaching children to swallow pills

Targeted interventions effective in teaching children to swallow pills

Variation in NICU antibiotic use not linked to outcomes

Variation in NICU antibiotic use not linked to outcomes

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Weighted vests and resistance training confer similar outcomes for bone density in the elderly
  • Breast cancer survivors may have a lower risk of Alzheimer’s dementia
  • Evaluating scar outcomes in pediatric burn patients following skin grafting 
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.