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EvidencePulse™ by 2 Minute Medicine 2026 evidence scan 3 reports You asked top stroke trials 2026 Synthesizing medical evidence... Top 2026 stroke trial results: OCEANIC — ischemic stroke: 6.2% vs 8.4% OPTION* — mRS 0–1: 43.6% vs 34.2% ORIENTAL* — mRS 0–2: 58.6% vs 46.6% *Higher sICH in intervention arms Participants randomizedN OCEANIC 12,327 OPTION 570 ORIENTAL 564 Ask about guidelines or landmark trials... ↑ Try EvidencePulse™ Ask the evidence.
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Home All Specialties Chronic Disease

Use of a mobile self-help application is associated with increased self-esteem and quality of life in individuals with intellectual disabilities

byJayden BerdugoandSimon Pan
January 13, 2026
in Chronic Disease, Imaging and Intervention, Psychiatry
Reading Time: 2 mins read
Shared decision-making tool for antidepressants improves patient and physician satisfaction
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1. In this randomized clinical trial, the use of a smartphone self-help app was associated with increased self-esteem and quality of life, and a decrease in depressive symptoms in individuals with intellectual disabilities (IDs). 

Evidence Rating Level: 1 (Excellent) 

Intellectual disabilities (IDs) affect a small portion of the population, and around 34% of these individuals also experience mental health issues, especially depression, anxiety, and psychosis. These conditions are underdiagnosed due to diagnostic overshadowing and reliance on self-reporting. Although cognitive behavioural therapy is helpful, access to mental health care in this population is limited. One possible effective treatment alternative is smartphone-based interventions. This randomized clinical trial tested a self-help app called Happy, designed to reduce depression and boost self-esteem in people with IDs. This study aimed to assess the extent to which the app was accepted and whether it could improve mental well-being. 99 participants were randomized 1:1 to the intervention group (n=50) or the waiting list control group (n=49). Among the included participants, 93 completed the postintervention assessment. The intervention group had a significantly greater reduction in depressive symptoms compared to the control group (F1, 97 = 7.52, P = .007) with a medium effect size (np2=0.072). The intervention group also showed improvements in quality of life (QoL) (F1,97 = 5.09; ηp2 = 0.050 [small to medium effect]) (P = .03) and self-esteem (F1,97 = 17.94; ηp2 = 0.156 [large effect]) (P < .001). Overall, this randomized clinical trial found that this self-help was effective in reducing depressive symptoms and improving self-esteem and quality of life in individuals with IDs. 

Click here to read this study in JAMA Network Open

Image: PD

©2025 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc. 

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