Tag: depression

1. In this meta-analysis, smoking cessation was associated with reduced symptoms of anxiety and depression. 2. Smoking cessation was also associated with lower stress, increased positive affect, and improved psychological quality of life as compared to individuals who continued smoking. Evidence Rating Level: 2 (Good) For some, smoking cigarettes is a form...
1. In this randomized control trial, individualized cognitive behavioral therapy (CBT) for prolonged grief disorder was superior to supportive therapy in reducing symptoms at both 6- and 12-month follow-up. 2. Participants in the CBT Grief-Help group also demonstrated decreased symptoms of depression, post-traumatic stress disorder (PTSD), and lower levels of...
1. Patients with prior episodes of critical illness requiring ICU admission were found to have an elevated risk of suicide and self-harm. 2. Suicide and self-harm were further correlated to the prevalence pre-existing psychiatric conditions as well as the receipt of life support. Evidence Rating Level: 2 (Good) Study Rundown: Due to...
Section 5: Psychedelic use in the long-term Serious adverse reactions have not been a recognized risk through ongoing research, though some are concerned about long-term use and the time at which psychedelic drug treatment should be considered. Psychotic disorders, when they occur in a very small group of people, they...
Section 2: Psychedelics for depression & trauma-related disorders Posttraumatic Stress Disorder (PTSD) and other trauma-related conditions are common across the globe and particularly pernicious among combat veterans. For patients who have not responded well to traditional first line pharmacotherapy or counselling, psychedelics may be considered as an alternative or adjunct...
Section 1: Psychedelics as a potential therapeutic option for psychiatric conditions Psychedelic drugs, such as lysergic acid diethylamide (LSD), was of interest to molecular psychiatry in the 1950s due to its considerable chemical similarity to serotonin (5-HT). In the context of a highly regulated system, the use of psychedelics in...
1. Systematic review found that social prescribing was associated with a reduction in depressive symptoms in patients with dementia without a diagnosis of major depressive disorder. 2. Non-drug interventions either alone or in combination with drug interventions may be the most efficacious intervention for these patients. Evidence Rating Level: 1 (Excellent) Study...
1. Psilocybin treatment was shown not to report significantly improved self-reported depression scores compared to escitalopram treatment in patients with major depressive disorder. 2. Secondary outcomes of other mental health scales may have improved with psilocybin treatment but could not be directly compared to escitalopram treatment. Evidence Rating Level: 1 (Excellent) Study...
1. Among adolescents with treatment-resistant depression, an infusion of ketamine significantly reduced depressive symptoms over a two-week period compared with an infusion of midazolam. Evidence Rating Level: 2 (Good) Study Rundown: Major depressive disorder (MDD) has a lifetime prevalence of nearly 20% by adolescence and is associated with substantial morbidity and...
1. Concomitant antidepressant and benzodiazepine therapy was associated with an increased risk of all-cause mortality over antidepressant monotherapy in patients with depression. Evidence Rating Level: 2 (Good) As antidepressants (ADs) may take several weeks to show therapeutic effect, benzodiazepines (BZDs) are often prescribed concomitantly to manage anxiety or insomnia in patients...