Tag: amyotrophic lateral sclerosis (ALS)

1. Sodium phenylbutyrate-taurursodiol slowed the functional decline in patients with amyotrophic lateral sclerosis. 2. The mean rate of change for slow vital capacity and plasma phosphorylated axonal neurofilament H subunit were not significantly different between the treatment and control groups. Evidence Rating Level: 1 (Excellent) Study Rundown: Amyotrophic lateral sclerosis (ALS) causes...
1. Sodium phenylbutyrate-taurursodial slowed the functional decline in patients with amyotrophic lateral sclerosis. 2. The mean rate of change for slow vital capacity and plasma phosphorylated axonal neurofilament H subunit were not significantly different between the treatment and control groups. Evidence Rating Level: 1 (Excellent) Study Rundown: Amyotrophic lateral sclerosis (ALS) causes...
1. A 100mg treatment of tofersen was shown to decrease cerebrospinal fluid (CSF) superoxide dismutase 1 (SOD1) concentration in adults with amyotrophic lateral sclerosis (ALS) due to SOD1 mutations. 2. Lumbar puncture-related adverse events were shown to be present in most participants. Evidence Rating Level: 1 (Excellent) Study Rundown: Amyotrophic lateral sclerosis,...
1. A 100mg treatment of tofersen was shown to decrease cerebrospinal fluid (CSF) superoxide dismutase 1 (SOD1) concentration in adults with amyotrophic lateral sclerosis (ALS) due to SOD1 mutations. 2. Lumbar puncture-related adverse events were shown to be present in most participants. Evidence Rating Level: 1 (Excellent) Study Rundown: Amyotrophic lateral sclerosis,...
Both multifocal motor neuropathy (MMN) and amyotrophic lateral sclerosis (ALS) affect the peripheral nervous system and present with palsies. Differentiating between these two diseases is important from a prognostic perspective, as MMN should be treated as early as possible with immunomodulatory therapy, while ALS is not currently treatable. Magnetic...
Amyotrophic Lateral Sclerosis versus Multifocal Motor Neuropathy: Utility of MR Neurography Both multifocal motor neuropathy (MMN) and amyotrophic lateral sclerosis (ALS) affect the peripheral nervous system and present with palsies. Differentiating between these two diseases is important from a prognostic perspective, as MMN should be treated as early as possible...