Tag: anticoagulation

Risk of Hospitalization with Hemorrhage Among Older Adults Taking Clarithromycin vs Azithromycin and Direct Oral Anticoagulants 1. Co-prescription of clarithromycin and direct oral anticoagulants was associated with a higher rate of 30-day hospitalization with hemorrhage when compared with co-prescription of azithromycin. Evidence Rating Level: 2 (Good) In recent years, direct oral anticoagulants...
1. After successful transcatheter aortic valve replacement, compared to an anti-platelet based strategy, patients that received an anti-coagulation strategy including rivaroxaban at a dose of 10 mg daily had a higher risk of death, thromboembolic complications, and bleeding. Evidence Rating: 1 (Excellent) Transcatheter aortic-valve replacement (TAVR) is a treatment option for patients...
Central venous thrombosis (CVT) is a form of stroke characterized by thrombosis of cerebral veins or dural sinuses. While less than 5% of the 1.3 to 1.6 per 100,000 who experience CVT die by this cause, those who survive are at an increased risk of venous thrombotic events, and...
1. In this randomized controlled trial, cold snare polypectomy with continuous anticoagulation does not increase bleeding risk when compared to hot snare polypectomy with heparin bridging. 2. The cold snare polypectomy procedure had shorter procedure time per lesion and decreased length of hospital stays in comparison to hot snare polypectomy. Evidence...
Venous thromboembolism (VTE) is common following major trauma. While delay in thromboprophylaxis initiation by more than 1 to 3 days is associated with a significantly increased risk of VTE and mortality, prophylaxis is also associated with an increased risk of progressive hematoma enlargement in the setting of traumatic brain...
Antiplatelet Therapy vs Anticoagulation Therapy in Cervical Artery Dissection: The Cervical Artery Dissection in Stroke Study (CADISS) Randomized Clinical Trial Final Results Cervical artery dissection is a common cause of ischemic stroke in young patients. Whether antiplatelet (AP) therapy or anticoagulation (AC) therapy is more effective at preventing recurrent stroke...
The risk of venous thromboembolism (VTE) is significantly increased in patients with active cancer. While parenteral prophylactic anticoagulation has been shown to reduce the risk of VTE in cancer patients, its use is associated with an increased risk of major bleeding and the inconvenience of daily injections. Direct oral...
Apixaban to Prevent Venous Thromboembolism in Patients with Cancer The risk of venous thromboembolism (VTE) is significantly increased in patients with active cancer. While parenteral prophylactic anticoagulation has been shown to reduce the risk of VTE in cancer patients, its use is associated with an increased risk of major bleeding...
1. In this retrospective cohort study, rivaroxaban had the highest and apixaban had the lowest upper gastrointestinal bleeding (UGIB) risk. 2. Proton Pump Inhibitor (PPI) co-therapy reduced UGIB risk, regardless of anticoagulant used. Evidence Rating Level: 2 (Good)         Study Rundown: Oral anticoagulants have a known risk of major upper gastrointestinal bleeding (UGIB),...
1. Prophylactic low-molecular-weight heparin (LMWH) for 8 days post knee arthroscopy demonstrated no change in the incidence of venous thromboembolism (VTE) or major bleeding events compared to placebo. 2. Prophylactic LMWH during the full period of immobilization due to casting of the lower extremity demonstrated no change in the incidence...