Tag: anticoagulation

1. Based on a matched control study of elderly patients for whom anticoagulation was indicated, bleeding risk was mildly higher in patients 90 or older and the same amongst patients 80-89 years old as compared with those between ages 70-79 years old. 2. The risk of thrombosis was significantly higher...
1. Patients with atrial fibrillation are at higher risk of ischemic stroke and systemic embolism. 2. Compared to placebo, warfarin and aspirin significantly reduced the risk of ischemic stroke and systemic embolism in patients with atrial fibrillation. 3. Today, antithrombotic therapy remains a vital consideration in managing patients with atrial fibrillation,...
1. Patients with atrial fibrillation are often treated with long-term oral anticoagulation, and may require interruption of their anticoagulation for elective surgeries or invasive procedures. 2. This study demonstrated that periprocedural bridging with dalteparin did not significantly reduce the risk of arterial thromboembolic disease when compared to placebo. 3. Patients treated...
1. In patients requiring percutaneous coronary intervention (PCI) and long-term oral anticoagulation, treating with clopidogrel alone (i.e., double therapy) significantly reduced the risk of bleeding when compared to a combination of aspirin and clopidogrel (i.e., triple therapy). 2. There were no differences between the two groups in the risk of...
1. Meta-analysis suggests that there is no difference in risk of access site hematoma, bleeding complication, or mortality between interrupted and uninterrupted warfarin therapy for arterial endovascular procedures. 2. For venous procedures, uninterrupted warfarin therapy was associated with a decreased risk of access site hematoma or bleeding complications, and secondary...
1. In a randomized controlled trial of over 300 patients with advanced pancreatic cancer treated in the outpatient setting, the use of a combined regimen of chemotherapy and prophylactic enoxaparin demonstrated significant reduction in the incidence of symptomatic venous thrombotic events compared to chemotherapy alone. 2. The addition of prophylactic...
1. Anticoagulated patients with soft tissue bleeding can successfully be treated with arterial embolization with a high degree of technical and clinical success. This is linked to reduced transfusion volume requirements. 2. Multiple detector computed tomography angiography is a sensitive technique for detecting soft tissue bleeding in suspected patients and selecting...
1. Patients who underwent bridging therapy with heparin during warfarin interruption for procedures had a significantly higher risk of bleed as compared to those who did not undergo bridging therapy. 2. Rates of recurrent venous thromboembolism were not significantly different across both groups. Evidence Rating Level: 2 (Good) Study Rundown: Warfarin is...
1. Cancer patients treated with 6 months of low molecular weight heparin (LMWH) for first-time DVT with no residual clot do not benefit from an additional 6 months of treatment with LMWH. Evidence Rating Level: 1 (Excellent) Study Rundown: Due to the hypercoagulable state associated with malignancy, cancer patients are at high...
Image: PD  1. Among patients with venous thromboembolism, clinically relevant bleeding and major bleeding increased with concomitant anticoagulant and NSAID use.   2. Concomitant Aspirin use also increased risk of major bleeding and clinically relevant bleeding. Evidence Rating Level: 2 (Good)  Study Rundown:  Anticoagulation is the standard of care for the treatment of...