Tag: antiplatelet

1. Standardized score suggests that prolonged dual antiplatelet therapy (DAPT) is harmful for patients with low DAPT scores. 2. Prolonged DAPT may reduce risk of ischemic events in patients with high scores receiving paclitaxel-eluting stents. Evidence Rating Level: 2 (Good) Study Rundown: The DAPT score is a new, standardized system of predicting...
1. A prediction model for assessing the harm and benefit of long-term dual antiplatelet therapy after percutaneous coronary intervention (PCI) was able to accurately identify patients with the highest risk of ischemia. 2. Patients with high-risk of ischemia after PCI who were maintained on aspirin and thienopyridine had a significantly...
1. In patients requiring percutaneous coronary intervention (PCI) and long-term oral anticoagulation, treating with clopidogrel alone (i.e., double therapy) significantly reduced the risk of bleeding when compared to a combination of aspirin and clopidogrel (i.e., triple therapy). 2. There were no differences between the two groups in the risk of...
1. From a systematic review, longer duration dual-antiplatelet therapy was associated with a decreased risk of myocardial infarction in patients with drug-eluting stents. 2. However, longer duration therapy also increased the risk of major bleeding and all-cause mortality. Evidence Rating Level: 1 (Excellent) Study Rundown: Patients with coronary artery disease (CAD) who...
1. Extended duration dual antiplatelet therapy was not found to be linked to an increased all-cause, cardiovascular, or non-cardiovascular mortality risk. Evidence Rating Level: 1 (Excellent) Study Rundown: Recent studies have shown conflicting evidence as to the safety of long term dual antiplatelet therapy for patients at risk of...
1. After 12 months of dual antiplatelet therapy, patients who continued on a thienopyridine in addition to aspirin for 18 months experienced significantly lower rates of stent thrombosis and myocardial infarction compared to those taking placebo. 2. The risk of bleeding was significantly higher in patients who continued on thienopyridine...
Classics Series, Landmark Trials in Medicine
1. Dual antiplatelet therapy with clopidogrel and aspirin was associated with a significant reduction in microembolic events in patients with symptomatic carotid stenosis compared to aspirin alone 2. There was no significant difference between the two groups in the risk of bleeding Original Date of Publication: May 3, 2005  Study Rundown: The...
Image: PD In this section, we will highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Three vs Twelve Months of Dual Antiplatelet Therapy After Zotarolimus-Eluting Stents: The OPTIMIZE Trial Studies ascertaining the optimal length of antiplatelet therapy after placement of drug-eluting stents have provided mixed...
Classics Series, Landmark Trials in Medicine
1. In patients with atrial fibrillation who require anticoagulation but cannot tolerate warfarin, dual anti-platelet therapy may be a potential alternative for stroke prophylaxis. 2. Clopidogrel, in addition to daily aspirin, significantly reduced the incidence of stroke, but increased the incidence of major bleeding in patients with atrial fibrillation when...