Tag: atherosclerosis

1. Ziltivekimab lowered high-sensitivity CRP levels, a predictor of vascular events, compared to placebo in a dose-dependent manner. 2. Thrombotic biomarkers including fibrinogen, serum amyloid A, haptoglobin, secretory phospholipase A2, and lipoprotein were lower in treatment groups compared to placebo. Evidence Rating Level: 1 (Excellent) Study Rundown: Prior studies, including the landmark...
1. Combined use of intracoronary near-infrared spectroscopy (NIRS) and intravascular ultrasound were effective at detecting untreated intracoronary lesions at high risk of major adverse cardiac event (MACE). 2. Highly lipidic lesions and large plaque burden were found to be independent predictors of non-culprit lesion-related MACEs. Evidence Rating Level: 2 (Good) Study Rundown:...
1. In individuals aged 70-100 years, there was a significantly increased risk of myocardial infarction and atherosclerotic cardiovascular disease for every 1.0 mmol/L increase in LDL cholesterol. 2. Individuals aged 80-100 years were found to have the lowest number needed to treat in 5 years to prevent one myocardial infarction. Evidence...
1. Among patients with vascular disease, high burden of atherosclerotic lesions in the posterior circulation as well as the posterior cerebral artery was associated with poorer memory and executive functioning. Evidence Rating Level: 2 (Good) The individual and societal burden of dementia continues to rise as the global population, on average,...
Intracranial Atherosclerosis on 7T MRI and Cognitive Functioning – the SMART-MR study 1. Among patients with vascular disease, high burden of atherosclerotic lesions in the posterior circulation as well as the posterior cerebral artery was associated with poorer memory and executive functioning. Evidence Rating Level: 2 (Good) The individual and societal burden...
1. Income drop is associated with a higher risk of subsequent cardiovascular disease, while income rise is associated with a lower risk of subsequent cardiovascular disease. Evidence Rating Level: 2 (Good) Low income has been robustly associated with an increased risk of cardiovascular disease (CVD). However, causality remains disputed, principally due...
1. In this systematic review and meta-analysis, use of low-dose aspirin in patients without symptomatic cardiovascular disease was linked with an increased risk of intracranial hemorrhage (ICH). 2. Risk of ICH was greatest amongst those with low body mass, or Asian ethnicity. Evidence Rating Level: 1 (Excellent)       Study Rundown: The use of low-dose...
1. In this systematic review and meta-analysis, use of low-dose aspirin in patients without symptomatic cardiovascular disease was linked with an increased risk of intracranial hemorrhage (ICH). 2. Risk of ICH was greatest amongst those with low body mass, or Asian ethnicity. Evidence Rating Level: 1 (Excellent)       Study Rundown: The use of...
1. In this cross-sectional study of subclinical atherosclerosis and sleep quality, sleep duration less than six hours per night was associated with increased probability of higher atherosclerotic burden on three-dimensional vascular ultrasound. 2. The participants with the highest degree of sleep fragmentation also had a higher prevalence of multiple atherosclerosis-affected...
1. In patients with severe cerebral small vessel disease, a strategy of intensive blood pressure control did not significantly alter whole brain blood flow when compared to standard blood pressure control. Evidence Rating Level: 2 (Good)           Study Rundown: Cerebral small vessel disease (SVD) is a common cause of ischemic stroke and...