Tag: atherosclerosis

Intracranial Atherosclerosis on 7T MRI and Cognitive Functioning – the SMART-MR study 1. Among patients with vascular disease, high burden of atherosclerotic lesions in the posterior circulation as well as the posterior cerebral artery was associated with poorer memory and executive functioning. Evidence Rating Level: 2 (Good) The individual and societal burden...
1. Income drop is associated with a higher risk of subsequent cardiovascular disease, while income rise is associated with a lower risk of subsequent cardiovascular disease. Evidence Rating Level: 2 (Good) Low income has been robustly associated with an increased risk of cardiovascular disease (CVD). However, causality remains disputed, principally due...
1. In this systematic review and meta-analysis, use of low-dose aspirin in patients without symptomatic cardiovascular disease was linked with an increased risk of intracranial hemorrhage (ICH). 2. Risk of ICH was greatest amongst those with low body mass, or Asian ethnicity. Evidence Rating Level: 1 (Excellent)       Study Rundown: The use of low-dose...
1. In this systematic review and meta-analysis, use of low-dose aspirin in patients without symptomatic cardiovascular disease was linked with an increased risk of intracranial hemorrhage (ICH). 2. Risk of ICH was greatest amongst those with low body mass, or Asian ethnicity. Evidence Rating Level: 1 (Excellent)       Study Rundown: The use of...
1. In this cross-sectional study of subclinical atherosclerosis and sleep quality, sleep duration less than six hours per night was associated with increased probability of higher atherosclerotic burden on three-dimensional vascular ultrasound. 2. The participants with the highest degree of sleep fragmentation also had a higher prevalence of multiple atherosclerosis-affected...
1. In patients with severe cerebral small vessel disease, a strategy of intensive blood pressure control did not significantly alter whole brain blood flow when compared to standard blood pressure control. Evidence Rating Level: 2 (Good)           Study Rundown: Cerebral small vessel disease (SVD) is a common cause of ischemic stroke and...
1. In patients with stroke who had intracranial atherosclerotic disease (ICAD), atherosclerotic disease in other vascular beds was more common including the aortic arch and coronary artery disease. 2. Patients who presented with stroke and ICAD were at greater risk of subsequent major adverse cardiovascular event (MACE) if they had...
1. Neighborhood socioeconomic position may have a significant impact on major atherosclerotic cardiovascular disease (ASCVD)-related events. 2. Population-based solutions targeted at reducing differences in neighborhood socioeconomic position may help improve ASCVD risk. Evidence Rating Level: 2 (Good) Study Rundown: The authors of this study aimed to evaluate the relationship between neighborhood socioeconomic...
1. In a prospective study of 62 patients with hidradenitis suppurativa (HS) and their matched controls, HS was associated with an increased risk of subclinical atherosclerosis in patients 40 years or older when corrected for traditional risk factors. Evidence Rating Level: 2 (Good)  Study Rundown: HS is a chronic, inflammatory skin...
1. For patients with atherosclerotic cardiovascular disease, PCSK9 inhibitors, either in monotherapy for statin-intolerant patients or in addition to statin therapy, was less cost-effective than adding ezetimibe. 2. Treating patients with heterozygous familial hypercholesterolemia with the addition of PCSK9 inhibitors was also less cost-effective than ezetimibe. Evidence Rating Level: 3 (Average) Study...