Tag: atopic dermatitis

1. Upadacitinib combined with topical corticosteroids reduced Eczema Area and Severity Index (EASI) and Investigator’s Global Assessment for atopic dermatitis (vIGA-AD) scores significantly more than placebo with corticosteroids. 2. Efficacy of upadacitinib combination therapy was comparable to upadacitinib monotherapy, suggesting potential for steroid-sparing treatment of atopic dermatitis. Evidence Rating Level: 1 (Excellent) Study Rundown: For...
1. Upadacitinib combined with topical corticosteroids reduced Eczema Area and Severity Index (EASI) and Investigator’s Global Assessment for atopic dermatitis (vIGA-AD) scores significantly more than placebo with corticosteroids. 2. Efficacy of upadacitinib combination therapy was comparable to upadacitinib monotherapy, suggesting potential for steroid-sparing treatment of atopic dermatitis. Evidence Rating Level: 1...
1. The proportion of patients with EASI ≥75% was significantly greater in the upadacitinib 30 mg and 15 mg groups than the placebo group. 2. Both upadacitinib doses were well tolerated, with the most common adverse events being acne and upper respiratory tract infection. Evidence Rating Level: 1 (Excellent) Study Rundown: Upadacitinib...
1. Individuals diagnosed with atopic dermatitis (AD) as children were at elevated risk of not attaining lower and upper secondary education, compared to the general population, although this association was not present for university education. 2. No difference in educational attainment was found when children with AD were compared to...
1. In this study, nemolizumab with topical agents and oral antihistamines when compared to topical agents and oral antihistamines alone reduced pruritis in atopic dermatitis patients 2. Among patients in the nemolizumab group, eczema area, quality of life and insomnia improved when compared with placebo. Evidence Rating Level: 1 (Excellent) Study Rundown:...
1. In this study, nemolizumab with topical agents and oral antihistamines when compared to topical agents and oral antihistamines alone reduced pruritis in atopic dermatitis patients 2. Among patients in the nemolizumab group, eczema area, quality of life and insomnia improved when compared with placebo. Evidence Rating Level: 1 (Excellent) Study Rundown:...
1. Commonly prescribed antibiotics in infancy are associated with later diagnosis of allergic disease in childhood Evidence Rating Level: 2 (Good) The use of antibiotics negatively impacts the human microbiome, decreasing bacterial diversity. These kinds of changes to the microbiome have been previously found to be associated with allergic disease. In...
1. In treatment-resistant childhood atopic dermatitis, omalizumab significantly reduced the severity of dermatitis and improved quality of life compared to placebo.  Evidence Rating Level: 1 (Excellent) Anti-IgE medications such as omalizumab are well-tolerated in patients with severe asthma and atopy; however, no large randomized trials have examined its efficacy in children experiencing...
1. In treatment-resistant childhood atopic dermatitis, omalizumab significantly reduced the severity of dermatitis and improved quality of life compared to placebo.  Evidence Rating Level: 1 (Excellent) Anti-IgE medications such as omalizumab are well-tolerated in patients with severe asthma and atopy; however, no large randomized trials have examined its efficacy in children...
Association of Anticoagulant Therapy With Risk of Fracture Among Patients With Atrial Fibrillation 1. Direct oral anticoagulants, specifically apixaban, were associated with lower risk of fracture in patients with atrial fibrillation compared to warfarin. Evidence Rating Level: 2 (Good) Warfarin is commonly used to prevent cardioembolic events in individuals with atrial fibrillation...