Tag: autologous stem cell transplantation

Autologous stem cell transplantation (ASCT) is commonly used in the treatment of multiple myeloma, though relapse is extremely common. Ixazomib is a proteasome inhibitor that has been suggested as a possible maintenance therapy for patients with multiple myeloma after they complete ASCT. In this multicenter, double-blind, randomized phase 3...
1. Scleroderma patients treated with myeloablative autologous stem-cell transplantation experienced significantly higher rates of disease-free survival at 52 months post-treatment compared to those treated with cyclophosphamide. 2. Treatment-related mortality occurred in some patients treated with stem-cell transplantation. Evidence Rating: 1 (Excellent) Study Rundown: Scleroderma is an autoimmune disorder often resulting in fatal...
1. Compared to placebo, letermovir prophylaxis significantly decreased the incidence of cytomegalovirus (CMV) infection through 24 weeks following hematopoietic stem cell transplantation (HSCT). 2. Letermovir was associated with a significantly lower all-cause mortality compared to placebo and did not demonstrate any serious toxicities. Evidence Rating Level: 1 (Excellent)       Study Rundown: While many...
1. This retrospective cohort study examined seven patients with myasthenia gravis (MG) refractory to immunosuppressive therapy who underwent autologous hematopoietic stem cell transplant (HCST) and demonstrated durable clinical remission. 2. Complications of autologous HSCT in this population included viral reactivation and secondary autoimmune conditions, but no treatment-related mortality was observed. Evidence...
1. Hematopoietic stem cell transplant (HSCT) did not significantly achieve disease remission in patients with refractory Crohn's disease. 2. More patients who underwent HSCT had a non-significant trend towards better quality of life and less active disease on imaging but also had a significantly higher number of infections than those...
1. In a prospective cohort study of over 120 Jehovah’s Witnesses with lymphoma and multiple myeloma, high-dose chemotherapy (HDC), and autologous stem-cell transplantation (ASCT) without transfusion support was associated with relatively low mortality and morbidities. Evidence Rating Level: 3 (Average) Study Rundown: The standard of care for high risk or recurrent...
1. Patients with chronic graft-vs-host disease (CGVHD) after allogeneic hematopoietic stem cell transplantation (AHSCT) were more likely to develop cutaneous autoimmune diseases when there was female donor to male recipient sex mismatch or if the patient had Anticardiolipin (ACA) IgG antibodies.                                            2. In patients with CGVHD, there was no...
In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Atrial Fibrillation in Patients with Cryptogenic Stroke Patients experiencing a stroke or transient ischemic attack (TIA) often undergo diagnostic workup involving 24 hour ECG monitoring for atrial fibrillation.  However, it is suspected...
Image: PD 1. Autologous stem-cell transplantation improved progression-free survival in patients with high-intermediate-risk and high-risk disease, but did not show improvement in overall survival. 2. Retrospective subgroup analysis suggests that early transplantation may provide greater benefit to patients with high-risk disease than patients with high-intermediate-risk disease. Evidence Rating Level: 2 (Good) Study Rundown:...
Image: PD RANKL protein structure 1. Continued monoclonal protein response to autologous stem cell transplantation (ASCT) is associated with improved progression-free survival, time to next therapy and overall survival. 2. This marker should be considered in post-transplant care of multiple myeloma (MM) patients. Evidence rating: 2 (Good) Study Rundown: The treatment options for multiple...