Tag: benzodiazepine

1. Co-prescription of benzodiazepines and z-drugs with opioid agonists was associated with a significantly increased risk of drug-related poisoning in opioid-dependent individuals. Evidence Rating Level: 2 (Good) Opioid agonist treatment (OAT) is common and effective for individuals with opioid dependence. Concurrent medications, particularly sedatives, prescribed alongside OAT may increase risk of...
Association of Anticoagulant Therapy With Risk of Fracture Among Patients With Atrial Fibrillation 1. Direct oral anticoagulants, specifically apixaban, were associated with lower risk of fracture in patients with atrial fibrillation compared to warfarin. Evidence Rating Level: 2 (Good) Warfarin is commonly used to prevent cardioembolic events in individuals with atrial fibrillation...
Strategies to amend clinician prescription patterns are of critical importance in addressing opioid abuse and opioid-related deaths across the United States. One potential approach involves targeting opioid-prescription practices in the perioperative period. However, little is known about the outcomes of patients who are prescribed opioids and other high-risk medications...
Association Between Preoperative Opioid and Benzodiazepine Prescription Patterns and Mortality After Noncardiac Surgery Strategies to amend clinician prescription patterns are of critical importance in addressing opioid abuse and opioid-related deaths across the United States. One potential approach involves targeting opioid-prescription practices in the perioperative period. However, little is known about...
Previous studies have shown that benzodiazepine use in early pregnancy is associated with spontaneous abortion (SA). The association between specific benzodiazepines and the risk of SA, however, has not been investigated. In this nested case-control study based in Montreal, Quebec, Canada, cases defined as any pregnancy loss between the...
Association between incidence exposure to benzodiazepines in early pregnancy and risk of spontaneous abortion Previous studies have shown that benzodiazepine use in early pregnancy is associated with spontaneous abortion (SA). The association between specific benzodiazepines and the risk of SA, however, has not been investigated. In this nested case-control study...
Convulsive status epilepticus (SE) is the most common life-threatening neurological emergency in pediatrics. It is associated with significant morbidity and mortality, with 22% of patients ultimately requiring intubation and intensive care unit admission. Benzodiazepines are used first-line in terminating seizure activity. However, when this fails, phenytoin is the current...
1. Of the over 9,000 annual hospitalizations of children under the age of 6 for unsupervised medication ingestions, opioids and benzodiazepines are the most commonly implicated medication classes. 2. Hospitalization rates for buprenorphine ingestion were significantly higher than rates for any other active medication ingredient. Evidence Rating Level: 2 (Good)  ...
1. There was an increased risk of Alzheimer’s disease among older adults who had ever used benzodiazepines, and an even higher risk for those who had used benzodiazepines for greater than the recommended 3 months. 2. The use of long-acting benzodiazepines was more strongly associated with Alzheimer’s disease than...
Image: PD 1. For patients withdrawing from alcohol, a symptom-triggered pharmacologic therapy may decrease detoxification time without compromising the safety or comfort of the patient 2. Symptom-triggered individualized benzodiazephine administration reduces the intensity and duration of oxazepam use during withdrawal treatment Original Date of Publication: May 27, 2002 Study Rundown: Fixed doses of...