Tag: cervical cancer

1. The FDA approved the expansion of the human papillomavirus (HPV) vaccination from ages 9 to 26 in women and 21 in men to 45 years in men and women. 2. This study predicted a small reduction in HPV-associated diseases and a substantially higher incremental cost-effectiveness ratios with extending the...
Genetically engineered T-cell therapies, such as chimeric antigen receptor T-cells (CAR T-cells), have been approved for the treatment of hematologic malignancies, however, there are limited data to support this approach in the management of epithelial cancers. Human papillomavirus (HPV)-associated epithelial cancers express viral E6 and E7 oncoproteins, which are...
1. This randomized controlled trial of women with early-stage cervical cancer reports that patients who underwent minimally invasive radical hysterectomy had lower rates of overall survival and disease-free survival at 4.5 years compared to women who underwent abdominal radical hysterectomy. 2. Women randomized to the minimally invasive group also...
1. A retrospective cohort study noted that minimally invasive surgery was associated with a higher risk of death compared to open surgery among women who underwent radical hysterectomy for early stage cervical cancer. 2. The advent of minimally invasive surgical techniques in 2006 was associated with a decline in 4-year...
1. From a cost-effectiveness analysis, current screening practices failed to outperform every other screening scenario in terms of health benefits and costs. 2. The major factors associated with improvement were routine cytologic screening every 3 years and perfect compliance with referrals for colposcopy/biopsy. Evidence Rating Level: 2 (Good) Study Rundown: Cervical cancer...
1. After clinical staging, one-third of cervical cancer patients were upstaged (found to have nodal or peritoneal spread) on laparoscopy. 2. Laparoscopic staging of advanced cervical cancer had low rates of complications and did not significantly delay initiation of chemoradiation. Evidence Rating Level: 1 (Excellent)     Study Rundown: While the incidence of cervical...
1. Oral oncogenic HPV prevalence was more than 4 times higher among men than women. 2.The gender difference was due primarily to a higher number of lifetime sexual partners and a stronger association between sexual behavior and infection among men. Evidence Rating Level: 3 (Average) Study Rundown: It is widely known that the...
1. In a small, prospective trial of nine patients with metastatic cervical cancer, three patients demonstrated complete or partial response after a single infusion of T-cells reactive to HPV oncoproteins. Evidence Rating Level: 3 (Average)     Study Rundown: Although the use of human papillomavirus (HPV) vaccination and screening programs may...

Patient Basics: Cervical Cancer

Originally published by Harvard Health. What Is It? The cervix is a small, donut-shaped structure. It is located at the top of the vagina. It is the entrance to the uterus. Cervical cancer begins in the outer layer of the cervix. This outer layer is called the cervical epithelium. Tiny changes begin...
1. Patients with CIN-2 who were treated with hexaminolevulinate 5% photodynamic therapy showed histological improvement. 2. This treatment method also demonstrated efficacy at clearance of HPV in patients with CIN-2. Evidence Rating Level: 1 (Excellent)   Study Rundown: Worldwide, cervical cancer is the leading causes of cancer death for women. Existing practices,...