Tag: dementia

1. There is a significantly increased risk of dementia in patients with previously diagnosed depression, with the highest risk observed in patients diagnosed with severe depression Evidence Level: 2 (Good) The prevalence of dementia is on the rise. With a scarcity of effective treatment options, increased emphasis has been placed on the...

The association of depression with subsequent dementia diagnosis: A Swedish nationwide cohort study from 1964 to 2016 1. There is a significantly increased risk of dementia in patients with previously diagnosed depression, with the highest risk observed in patients diagnosed with severe depression Evidence Level: 2 (Good) The prevalence of dementia is on...

Selective Vulnerability of the Nucleus Basalis of Meynert Among Neuropathologic Subtypes of Alzheimer Disease 1. Widespread cholinergic deficits found in early-onset Alzheimer’s disease (AD) may be a result of neurofibrillary tangle accumulation in the nucleus basalis of Meynert, specifically in those with hippocampal sparing AD. Evidence Rating Level: 1 (Excellent) The nucleus basalis...

1. A model of dementia care management implemented through telephone and internet was shown to be more effective in improving health outcomes in patients with dementia, mood, and caregiver burden compared to standard care alone. Evidence Rating Level: 1 (Excellent) The use of dementia care management programs for patients with...

The clinical effectiveness of sertraline in primary care and the role of depression severity and duration (PANDA): a pragmatic, double-blind, placebo-controlled randomised trial 1. Selective serotonin reuptake inhibitors (SSRIs) are not associated with significant short-term reductions in depressive symptoms in the primary care setting, but reduce short-term anxiety and improve...

1. In this retrospective cohort study, patients with high polygenic risk scores and unhealthy lifestyle factors were more likely to be diagnosed with dementia than patients with low polygenic risk scores or healthy lifestyle factors. 2. Polygenic risk scores and lifestyle factors independently influenced dementia risk. Evidence Rating Level: 2 (Good) Study...

With an increasing prevalence of dementia in the elderly population and treatment strategies limited to improving symptoms, there is a need to identify at-risk patients. Hearing loss (HL) has been identified as a risk factor for dementia, contributing to social isolation, depression and lower quality of life. In this...

1. In this prospective cohort study, patients with midlife hypertension and either late-life hypertension or hypotension had higher risks of dementia than mid-life normotensive participants. 2. Midlife hypertension and late-life hypotension were also associated with greater risk of mild cognitive impairment. Evidence Rating Level: 2 (Good) Study Rundown: Though midlife hypertension has...

Hospital volume and outcomes for acute pulmonary embolism: multinational population-based cohort study Patients with pulmonary embolism (PE) can present with a myriad of symptoms, and without prompt recognition and treatment, are at risk of developing life-threatening complications. The authors of this multinational population-based cohort study (n=39,257) aimed to evaluate whether...

1. In this retrospective cohort study, patients with high polygenic risk scores and unhealthy lifestyle factors were more likely to be diagnosed with dementia than patients with low polygenic risk scores or healthy lifestyle factors. 2. Polygenic risk scores and lifestyle factors independently influenced dementia risk. Evidence Rating Level: 2 (Good) Study...