Tag: dementia

1. Among patients with vascular disease, high burden of atherosclerotic lesions in the posterior circulation as well as the posterior cerebral artery was associated with poorer memory and executive functioning. Evidence Rating Level: 2 (Good) The individual and societal burden of dementia continues to rise as the global population, on average,...
1. Early-life cognitive enrichment was associated with decreased Alzheimer’s disease pathology and cognitive decline in late-life. Evidence Rating Level: 2 (Good) Factors such as educational performance and childhood socioeconomic status impact cognitive decline and Alzheimer’s disease- (AD) related pathology later in life. While these are components of early-life cognitive enrichment (ECLE),...
1. This protein-wide association study found that eight specific proteins were associated with cognitive resilience in older adults, pointing toward targets for novel therapies. Evidence Rating Level: 2 (Good) Many primary causes of dementia occur among older adults present without commonly recognized neuropathological signatures. Proteomics can be useful in identifying proteins...
Association of Early-Life Cognitive Enrichment With Alzheimer’s Disease Pathological Changes and Cognitive Decline 1. Early-life cognitive enrichment was associated with decreased Alzheimer’s disease pathology and cognitive decline in late-life. Evidence Rating Level: 2 (Good) Factors such as educational performance and childhood socioeconomic status impact cognitive decline and Alzheimer’s disease- (AD) related pathology...
1. Preclinical amyloid-β was associated with significant cognitive decline in clinically normal adults across screening and comprehensive measures. 2. Amyloid-β-positive individuals were more likely to carry at least one APOE ε4 allele and have a family history of dementia. Evidence Rating Level: 3 (Average) Amyloid-β (Aβ) pathology is known as the preclinical phase of...
1. Exposure to higher levels of air pollutants was associated with increased dementia incidence, with the 5 years preceding onset being the most impactful. 2. The association between dementia and air pollutant exposure was amplified in patients with cardiovascular disease, specifically heart failure and ischemic heart disease. Evidence Rating: 2 (Good) With increasing...
Association of a Care Bundle for Early Sepsis Management With Mortality Among Patients With Hospital-Onset or Community-Onset Sepsis 1. Sepsis bundles were not significantly associated with decreased risk of mortality or reduced vasopressor treatment time in community- or hospital-onset sepsis. 2. Components of the SEP-1 bundle, such as broad-spectrum IV antibiotic...
1. Large variations in blood pressure, including large rises and falls in blood pressure, over a period of years is associated with an increased long-term risk of dementia. Evidence Rating: 1 (Excellent) Dementia is highly prevalent affecting in the elderly, and represents a major burden to the healthcare system given...
1. There is a significantly increased risk of dementia in patients with previously diagnosed depression, with the highest risk observed in patients diagnosed with severe depression Evidence Level: 2 (Good) The prevalence of dementia is on the rise. With a scarcity of effective treatment options, increased emphasis has been placed on the...
The association of depression with subsequent dementia diagnosis: A Swedish nationwide cohort study from 1964 to 2016 1. There is a significantly increased risk of dementia in patients with previously diagnosed depression, with the highest risk observed in patients diagnosed with severe depression Evidence Level: 2 (Good) The prevalence of dementia is on...