Tag: dementia

1. Causes of death reported on death certificates drastically underestimated dementia mortality burden by a factor of 2.7. 2. Non-Hispanic Black persons demonstrated significantly greater mortality burden than non-Hispanic White persons. Evidence Rating Level: 2 (Good) Dementia is a leading cause of death in the US and abroad, with Alzheimer’s disease accounting...
Hyperthyroidism is associated with breast cancer risk and mammographic and genetic risk predictors 1. Hyperthyroidism was associated with a higher rate of breast cancer among women. 2. Risk was particularly elevated for those with toxic nodular goiter. Evidence Rating Level: 2 (Good) Breast cancer is the most common cancer among women across the...
1. Among patients with vascular disease, high burden of atherosclerotic lesions in the posterior circulation as well as the posterior cerebral artery was associated with poorer memory and executive functioning. Evidence Rating Level: 2 (Good) The individual and societal burden of dementia continues to rise as the global population, on average,...
1. Early-life cognitive enrichment was associated with decreased Alzheimer’s disease pathology and cognitive decline in late-life. Evidence Rating Level: 2 (Good) Factors such as educational performance and childhood socioeconomic status impact cognitive decline and Alzheimer’s disease- (AD) related pathology later in life. While these are components of early-life cognitive enrichment (ECLE),...
1. This protein-wide association study found that eight specific proteins were associated with cognitive resilience in older adults, pointing toward targets for novel therapies. Evidence Rating Level: 2 (Good) Many primary causes of dementia occur among older adults present without commonly recognized neuropathological signatures. Proteomics can be useful in identifying proteins...
Association of Early-Life Cognitive Enrichment With Alzheimer’s Disease Pathological Changes and Cognitive Decline 1. Early-life cognitive enrichment was associated with decreased Alzheimer’s disease pathology and cognitive decline in late-life. Evidence Rating Level: 2 (Good) Factors such as educational performance and childhood socioeconomic status impact cognitive decline and Alzheimer’s disease- (AD) related pathology...
1. Preclinical amyloid-β was associated with significant cognitive decline in clinically normal adults across screening and comprehensive measures. 2. Amyloid-β-positive individuals were more likely to carry at least one APOE ε4 allele and have a family history of dementia. Evidence Rating Level: 3 (Average) Amyloid-β (Aβ) pathology is known as the preclinical phase of...
1. Exposure to higher levels of air pollutants was associated with increased dementia incidence, with the 5 years preceding onset being the most impactful. 2. The association between dementia and air pollutant exposure was amplified in patients with cardiovascular disease, specifically heart failure and ischemic heart disease. Evidence Rating: 2 (Good) With increasing...
Association of a Care Bundle for Early Sepsis Management With Mortality Among Patients With Hospital-Onset or Community-Onset Sepsis 1. Sepsis bundles were not significantly associated with decreased risk of mortality or reduced vasopressor treatment time in community- or hospital-onset sepsis. 2. Components of the SEP-1 bundle, such as broad-spectrum IV antibiotic...
1. Large variations in blood pressure, including large rises and falls in blood pressure, over a period of years is associated with an increased long-term risk of dementia. Evidence Rating: 1 (Excellent) Dementia is highly prevalent affecting in the elderly, and represents a major burden to the healthcare system given...