Tag: dementia

1. Pimavanserin was shown to lead to a lower risk of relapse of psychosis in patients who had an initial response to pimavanserin for dementia-related psychosis.   2. The trial was stopped early for efficacy. Evidence Rating Level: 1 (Excellent) Study Rundown: Dementia-related psychosis results in behavioral disturbances, decreased quality of life,...
1. The use of menopausal hormone therapy was not associated with an increased risk of developing dementia or Alzheimer’s disease  2. Estrogen-only therapy for 10 years or more was associated with a decreased risk of dementia  Evidence Rating Level: 3 (Average)  Approximately 80% of women experiencing menopause report symptoms including hot flashes,...
1. Increasing age is associated with decrease in brain tissue, reduced volume of the amygdala, and cognitive decline  2. Regular meditation may slow the age-related deterioration process Evidence Rating Level: 3 (Average) Meditation has been studied for its holistic impacts on the physical, emotional, and spiritual health of individuals. One specific subregion...
1. In the context of elevated amyloid-beta, IL-12p70 was associated with slower cognitive decline. 2. IFN-γ was associated with slower cognitive decline irrespective of amyloid-beta deposition. Evidence Rating Level: 2 (Good) It is currently understood that immune dysregulation, as well as premature immunosenescence and cytokine levels, impact the neurodegenerative process. Less understood,...
1. Younger age of onset of type 2 diabetes mellitus is strongly associated with increased risk of subsequent dementia Evidence Rating Level: 2 (Good) Study Rundown: 34.2 million Americans  (10% of the U.S. population) have type 2 diabetes mellitus, and approximately 1 in 3 American adults have pre-diabetes. While the wide...
1. Systematic review found that social prescribing was associated with a reduction in depressive symptoms in patients with dementia without a diagnosis of major depressive disorder. 2. Non-drug interventions either alone or in combination with drug interventions may be the most efficacious intervention for these patients. Evidence Rating Level: 1 (Excellent) Study...
1. Causes of death reported on death certificates drastically underestimated dementia mortality burden by a factor of 2.7. 2. Non-Hispanic Black persons demonstrated significantly greater mortality burden than non-Hispanic White persons. Evidence Rating Level: 2 (Good) Dementia is a leading cause of death in the US and abroad, with Alzheimer’s disease accounting...
Hyperthyroidism is associated with breast cancer risk and mammographic and genetic risk predictors 1. Hyperthyroidism was associated with a higher rate of breast cancer among women. 2. Risk was particularly elevated for those with toxic nodular goiter. Evidence Rating Level: 2 (Good) Breast cancer is the most common cancer among women across the...
1. Among patients with vascular disease, high burden of atherosclerotic lesions in the posterior circulation as well as the posterior cerebral artery was associated with poorer memory and executive functioning. Evidence Rating Level: 2 (Good) The individual and societal burden of dementia continues to rise as the global population, on average,...
1. Early-life cognitive enrichment was associated with decreased Alzheimer’s disease pathology and cognitive decline in late-life. Evidence Rating Level: 2 (Good) Factors such as educational performance and childhood socioeconomic status impact cognitive decline and Alzheimer’s disease- (AD) related pathology later in life. While these are components of early-life cognitive enrichment (ECLE),...