Tag: dementia

Androgen deprivation therapy (ADT) is used in the treatment of prostate cancer, either alone or in combination with other treatment modalities. ADT, however, is not without long-term effects, with patients commonly experiencing sexual dysfunction, in addition to conferring an increased risk of cardiovascular events. ADT exposure may also increase...
2-cm versus 4-cm surgical excision margins for primary cutaneous melanoma thicker than 2 mm: long-term follow-up of a multicentre, randomised trial The ideal surgical excision margin for patients with thick (>2 mm) localized cutaneous melanomas is unclear, where the risk of recurrence must be weighed against excess morbidity resulting from...
1. In this prospective cohort, Alzheimer’s Disease biomarkers derived from imaging, namely amyloid, tau, and cortical thickness estimates, had a moderate impact in predicting memory decline compared to a clinical model. 2. Patients that were positive for amyloid and at least one other biomarker had a faster rate of decline...
1. Verubecestat, an orally administered beta amyloid precursor protein-cleaving enzyme 1 (BACE-1) inhibitor , did not slow or prevent the progression of dementia among patients with prodromal Alzheimer’s disease. 2. Adverse events were more often noted in the verubecestat groups compared to placebo. Evidence Rating Level: 1 (Excellent) Study Rundown: Prodromal Alzheimer’s disease...
1. In this prospective cohort study on aging, poor scam awareness measured by questionnaire was associated with an increased risk of Alzheimer’s Dementia (AD), mild cognitive impairment (MCI), and a higher burden of Alzheimer’s pathology in the brain. 2. These findings suggested that complex behavior decline precedes cognitive decline in...
1. In this prospective cohort study, a healthier diet in midlife did not affect the risk of developing dementia compared to unhealthier diets. 2. Patients who would go on to develop dementia were more likely to have unhealthier diets in later life. Evidence Rating Level: 2 (Good) Study Rundown: Dementia is an...
1. In this randomized controlled trial, intensive blood pressure lowering in elderly patients reduced the risk of developing Mild Cognitive Impairment (MCI) compared to standard blood pressure lowering. 2. While there was no difference in the risk of dementia between groups, the trial was terminated early due to observed cardiovascular...
1. In this randomized controlled trial, intensive blood pressure lowering in elderly patients reduced the risk of developing Mild Cognitive Impairment (MCI) compared to standard blood pressure lowering. 2. While there was no difference in the risk of dementia between groups, the trial was terminated early due to observed cardiovascular...
Pre-eclampsia is defined as new onset hypertension accompanied by signs of organ dysfunction in the setting of pregnancy. Unfortunately, the risks associated with pre-eclampsia extend beyond the time of pregnancy, as affected women are more likely to later develop hypertension, cardiovascular disease, diabetes and experience stroke. As a vascular...
1. In this prospective cohort study, older patients with more optimal cardiovascular (CV) health metrics had a lower rate of developing dementia in a dose-dependent manner. 2. Similarly, the rate of cognitive decline was slower in those with more optimal CV health metrics. Evidence Rating Level: 2 (Good) Study Rundown: The AHA...