Tag: dementia

Perioperative Bridging Anticoagulation in Patients with Atrial Fibrillation Anticoagulation with warfarin for stroke prevention in atrial fibrillation must be interrupted in patients who undergo elective operations. The need to bridge anticoagulation during the perioperative period is uncertain. In this international multicenter study, the authors performed a randomized, double-blind, placebo-controlled trial...
1. In this study, physical activity, compared to a health education program, did not result in significant improvements from baseline in global or domain-specific cognitive function in sedentary adults aged 70-89 years. 2. There was also no significant difference in the incidence of mild cognitive impairment (MCI) or dementia between...
Tinazaparin vs Warfarin for Treatment of Acute Venous Thromboembolism in Patients with Active Cancer: A Randomized Clinical Trial Cancer-associated venous thromboembolism (VTE) represents a major source of morbidity and mortality among patients receiving systemic chemotherapy. Based largely on the results of a single, large randomized trial and several smaller studies,...
1. In this systematic review and meta-analysis, out of 10 alternative screening tests, the best freely available alternatives to the Mini-Mental State Examination in screening for dementia were the Mini-Cog and Addenbrooke’s Cognitive Examination (ACE-R) tests. 2. Moreover, it was found that the best freely available alternative to the Mini-Mental...
1. There was a greater association between criminality and behavioral variant frontotemporal dementia (bvFTD) than there was between criminality and Alzheimer disease (AD). 2. Patients with bvFTD were significantly more likely to have criminal behavior as a first presentation of disease. There was also a trend in patients with bvFTD...
1. The STrAtegies for RelaTives (START) intervention provided to caregivers of dementia patients was linked to a seven-fold reduction in clinically significant depression than compared to receiving treatment as usual. 2. The START intervention was demonstrated to be cost effective as defined by National Institute for Health and Care thresholds...

Patient Basics: Dementia

Originally published by Harvard Health. What Is It? Dementia is a pattern of mental decline caused by different diseases or conditions. Most commonly, dementia occurs when brain nerve cells (neurons) die, and connections between neurons are interrupted. These disruptions have a variety of causes and usually cannot be reversed. Among the causes of...
In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Clinical Illness and Outcomes in Patients with Ebola in Sierra Leone With more than 10,100 reported cases, the current Ebola virus disease (EVD) outbreak is the largest and most widespread outbreak in...
1. Among cognitively-intact elderly adults, magnetic resonance (MR) imaging using an arterial spin labeling (ASL) technique was shown to predict cognitive decline after 18 months of follow-up. 2. Similar ASL neuroimaging findings were identified in healthy patients that progressed to cognitive decline as compared to control subjects with known mild...
1. There was an increased risk of Alzheimer’s disease among older adults who had ever used benzodiazepines, and an even higher risk for those who had used benzodiazepines for greater than the recommended 3 months. 2. The use of long-acting benzodiazepines was more strongly associated with Alzheimer’s disease than...