Tag: dementia

1. Based on results of the Atherosclerotic Risk in Communities (ARIC) prospective cohort, midlife vascular risk factors associated with dementia included smoking, diabetes, prehypertension, and hypertension. 2. Other risk factors associated with dementia included black race, older age, lower educational attainment, and APOE ε4 genotype. Evidence Rating Level: 2 (Good) Study Rundown:...

1. In this prospective cohort study, the presence of vascular risk factors during midlife were associated with higher brain amyloid in later life. 2. Higher midlife BMI was associated with higher amyloid burden in later life. Evidence Rating Level: 2 (Good) Study Rundown: Many preclinical studies have found evidence of an association...

1. Based on this double-blind randomized, controlled trial which evolved into a cohort study, asymptomatic men taking vitamin E, selenium or a combination of the two did not have decreased risk of dementia as compared to men taking placebo. 2. When the study transitioned from a randomized, controlled trial to...

1. This prospective cohort study showed that mentally stimulating activities (computer use, craft activities, social activities and playing games) in late-age (>70 years old) were associated with decreased risk of incident mild cognitive impairment (MCI). 2. When stratified by apolipoprotein E ε4 (APOE ε4) carrier status, those at lowest risk...

Adjuvant sunitinib in high-risk renal cell carcinoma after nephrectomy Sunitinib is a vascular endothelial growth factor pathway inhibitor used for treatment of metastatic renal cell carcinoma, however its efficacy in the setting of patients with non-metastatic renal cell carcinoma at high risk for recurrence after nephrectomy has not been largely...

1. Higher rates of potentially unsafe medication (PUM) prescribing were associated with veterans with dementia using dual healthcare systems. 2. Dual users were exposed to an additional month of high anticholinergic burden (ACB) and an additional week of antipsychotics. Evidence Rating Level: 2 (Good) Study Rundown: Dementia care poses a significant challenge...

1. Regardless of treatment intervention, all patients had progressive functional decline. 2. No statistically significant difference was observed in Activity of Daily Living Scale (ADL) for patients receiving occupational therapy versus no occupational therapy after 1 year. Evidence Rating Level: 1 (Excellent) Study Rundown: Alzheimer disease leads to progressive functional decline and...

A population-based study of cardiovascular mortality following early-stage breast cancer The disease-specific survival for women treated for early-stage breast cancer (EBC) has improved substantially. However, there is overlap between risk factors for breast cancer and cardiovascular disease, and treatments for the former have been associated with adverse cardiovascular effects. In...

1. Family and unpaid caregivers provide significant support to older adults with disability living in the community. Caregivers providing substantial assistance compared to some or no assistance experienced greater emotional, physical, and financial difficulty. They were also limited in valued activities and had lower work productivity. 2. Use of support...

1. In the Framingham Heart Study, there has been a declining incidence of dementia over three decades, spanning from the late 1970s to the present. 2. The declining incidence of dementia has been largely limited to those with at least a high school diploma and was only partially explained...