Tag: diabetes mellitus

1. Matched cohort meta-analysis showed significant morality and life expectancy benefits with metabolic–bariatric surgery compared to non-surgical management of obesity. 2. Survival benefits of bariatric surgery more apparent for individuals with type 2 diabetes.  Evidence Rating Level: 1 (Excellent) Study Rundown: Metabolic syndrome has been associated with significant morbidity and mortality, increasing...
1. Semaglutide 2.4 mg combined with once weekly cagrilintide therapy was not associated with increase in adverse events compared to semaglutide alone. 2. Compared to control, combined cagrilintide and semaglutide improved glycemic parameters and mean body weight reduction at 20 weeks. Evidence Rating Level: 1 (Excellent)  Study Rundown: Semaglutide is a glucagon-like...
1. Hospital readmission and mortality rates were higher in post-COVID patients as compared to matched control groups. 2. More diagnoses of respiratory disease, diabetes, and cardiovascular events were observed in post COVID patients. 3. Older and non-white individuals were at the highest risk for post-COVID complications. Evidence Rating Level: 2 (Good) Study Rundown:...
1. Change in mean bodyweight was -9.6% with semaglutide 2.4 mg vs. -3.4% with placebo. 2. Approximately two-thirds of patients on semaglutide 2.4 mg achieved a target HbA1c of 6.5% or less.  Evidence Rating Level: 1 (Excellent) Study Rundown: There is strong overlap between weight gain and type 2 diabetes, with the...
1. Compared to patients of European descent, poorer health outcomes were seen among Māori and Pacific New Zealanders with type 2 diabetes. 2. Māori patients had the highest incidence rate of all-cause mortality, cardiovascular mortality, and cancer mortality. Evidence Rating Level: 2 (Good) Study Rundown: Disparities associated with ethnicity and socioeconomic status...
1. 10-year remission rates were significantly higher for Roux-en-Y gastric bypass (RYGB) and biliopancreatic diversion (BPD) than medical therapy. 2. Patients in the BPD and RYGB groups had fewer diabetes-related complications.  Evidence Rating Level: 1 (Excellent) Study Rundown: Compared to conventional therapy, metabolic surgery results in significant short-term improvements among patients with...
1. Participants using the novel advanced hybrid insulin delivery system (Medtronic) had a greater proportion of time spent in their target glucose range versus control. 2. Proportion of time spent in hypoglycemic ranges was non-inferior between the Medtronic and control groups. Evidence Rating Level: 1 (Excellent) Study Rundown: Although various technological advances...
1. Sotagliflozin was shown to lower the risk of total number of deaths from cardiovascular causes and hospitalizations and urgent visits for heart failure in patients with diabetes and recent worsening heart failure compared to placebo. 2. Sotagliflozin was shown to be similar in the percentage of patients with adverse...
1. Finerenone treatment lowered the risk of chronic kidney disease (CKD) progression in patients diagnosed with type 2 diabetes and advanced CKD. 2. Treatment with finerenone also lowered the risk of cardiovascular events in patients diagnosed with type 2 diabetes and advanced CKD. Evidence Rating Level: 1 (Excellent) Study Rundown: The leading...
1. The use of sodium-glucose cotransporter-2 (SGLT-2i) increased study participants’ risk of diabetic ketoacidosis (DKA) hospital presentations when compared to dipeptidyl peptidase 4 inhibitors 2. Amongst all the sodium-glucose cotransporter-2 inhibitors included in the study, canagliflozin demonstrated the highest risk of DKA hospital presentations Evidence Rating Level: 2 (Good) Study Rundown: Sodium-glucose...