Tag: diabetes mellitus

1. The use of sodium-glucose cotransporter-2 (SGLT-2i) increased study participants’ risk of diabetic ketoacidosis (DKA) hospital presentations when compared to dipeptidyl peptidase 4 inhibitors 2. Amongst all the sodium-glucose cotransporter-2 inhibitors included in the study, canagliflozin demonstrated the highest risk of DKA hospital presentations Evidence Rating Level: 2 (Good) Study Rundown: Sodium-glucose...
1. In this randomized trial, diabetic patients with stable chest pain randomized to coronary computed tomographic angiography (CTA) had lower rates of cardiovascular death and myocardial infarction than those randomized to functional stress testing. 2. This benefit of the coronary CTA was not seen in nondiabetic patients. Evidence Rating Level: 1...
1. In this retrospective cohort study, mean HbA1c levels decreased prior to systematic implementation of a program to switch from analogue to human insulin, after which HbA1c levels then increased slightly and remained steady. 2. Serious hypoglycemic or hyperglycemic events were not significantly different with program implementation. Evidence Rating Level: 2...
1. Basal insulin analogues do not differ significantly in providing glucose control. 2. Some insulin formulations may have more favorable effects on patient weight compared to others. Evidence Rating Level: 1 (Excellent) Study Rundown: Type 2 diabetes (T2DM) has significant morbidity if untreated and affects a large proportion of North Americans annually....
1. In this retrospective cohort study, for patients with type 2 diabetes, initiation of a basal insulin analog compared with NPH insulin was not associated with a reduced risk of hypoglycemia-related ED visits or hospital admissions. 2. Though NPH insulin led to a small but significantly greater decrease in HbA1c...
1. Single blood sample looking at fasting glucose and HbA1c was a key predictor of subsequent diagnosis of diabetes. 2. Results suggest that a single sample blood test may be used in clinics in the confirmation of undiagnosed diabetes. Evidence Rating Level: 2 (Good) Study Rundown: The number of patients affected by...
1. SGLT-2 or GLP-1 agonists were associated with lower mortality than DPP-4 inhibitors, placebo, or no treatment. 2. Use of DPP-4 inhibitors was not associated with lower mortality than placebo or no treatment. Evidence Rating Level: 1 (Excellent) Study Rundown: Excess mortality and cardiovascular comorbidity is a concern in patients with type...
1. Compared to men who were never overweight, those overweight at age 7 who returned to a normal body mass index (BMI) by age 13 had no increased risk for developing type 2 diabetes. 2. Men overweight at age 13 who returned to normal weight by adulthood had an increased...
1. In this meta-analysis of studies that evaluated the rate of diabetes development in high risk individuals, lifestyle modifications (LSM) and certain classes of medications were found to be effective at reducing risk. 2. Lifestyle modifications demonstrated a persistent effect on risk reduction for diabetes, while the observed effects from...
1. In adolescents with type 1 diabetes mellitus, the albumin-to-creatinine ratio was not significantly changed by angiotensin-converting-enzyme (ACE) inhibitors alone, statins alone, or the two in combination compared to placebo. 2. In this population, ACE-inhibitors and statins did not demonstrate a significant benefit on other markers of diabetic vascular complications...