Tag: diabetes mellitus

1. A group of patients who newly initiated statins, compared to one that newly initiated another type of type 2 diabetes medication, had an increased odds of their diabetes progressing. 2. Participants with the greatest LDL cholesterol reduction had the worst diabetes progression. Evidence Rating Level: 2 (Good) Study Rundown: Statins are...

1. Topical application of ON101, a macrophage regulator cream, demonstrated superior therapeutic efficacy in the treatment of diabetic foot ulcers compared to standard absorbent dressing in terms of both complete healing rate and time to complete healing. 2. Therapeutic efficacy of ON101 was sustained in patients with high-risk factors including...

1. Topical application of ON101, a macrophage regulator cream, demonstrated superior therapeutic efficacy in the treatment of diabetic foot ulcers compared to standard absorbent dressing in terms of both complete healing rate and time to complete healing. 2. Therapeutic efficacy of ON101 was sustained in patients with high-risk factors including...

1. This cross-sectional study discovered that the estimated prevalence of both type 1 and type 2 diabetes among youths in the United States increased from 2001 to 2017. 2. The most substantial increases were observed in non-Hispanic White and non-Hispanic Black youths for type 1 diabetes and non-Hispanic Black and...

1. Patients receiving tirzepatide (5, 10, or 15 mg) reported significantly greater reductions in HbA1c compared to daily insulin degludec at 52 weeks post-randomization. 2. Tirzepatide (5, 10, or 15 mg) was superior to insulin degludec for the bodyweight reductions at 52 weeks post-randomization. Evidence Rating Level: 1 (Excellent) Study Rundown: Current...

1. In a randomized trial, factors associated with a decline in glucose-corrected sodium in children experiencing diabetic ketoacidosis (DKA) included older age, previous diagnosis of diabetes, higher initial glucose-corrected sodium and chloride concentrations, and treatment with 0.45% sodium chloride 2. There was no association between decline in glucose-corrected sodium concentration...

1. Standard BMI thresholds associated with greater risk of diabetes varied across 57 low- and middle-income countries depending on geographical region. 2. Younger individuals are also at greater risk of diabetes depending on geographical region, notably for men aged 25-34 in sub-Saharan Africa.  Evidence Rating Level: 2 (Good) Study Rundown: Body mass...

1. Tirzepatide was superior to placebo with regard to changes in HbA1c, serum glucose, body weight loss, and proportion of patients achieving HbA1c targets of less than 7.0%. 2. Compared to placebo, the proportion of adverse events with tirzepatide were mildly elevated. Evidence Rating Level: 1 (Excellent) Study Rundown: In many patients...

1. Time spent cycling was associated with lower all-cause and cardiovascular disease-specific mortality in this multicenter European cohort study of patients with diabetes, independent of other exercise. 2. Taking up cycling over a five-year period was associated with lower mortality rates compared with those who did not cycle at all. Evidence...

1. In patients with type 2 diabetes, use of sodium-glucose cotransporter 2 inhibitors was associated with reduced risk of all-cause mortality compared with sulfonylureas, regardless of cardiovascular disease status, estimated glomerular filtration rate category, and albuminuria status. 2. The addition of SGLT2 inhibitor as a second-line antihyperglycemic agent with metformin...