Tag: glaucoma

1. Treatment using laser trabeculoplasty and topical betaxolol hydrochloride to reduce intraocular pressure (IOP) is associated with delayed progression of glaucoma 2. Treatment to decrease IOP was associated with an increase in nuclear lens opacity grading indicative of cataract formation Original Date of Publication: October 2002 Study Rundown: Previous epidemiological studies had...
Classics Series, Landmark Trials in Medicine
1. Reduction of intra-ocular pressure (IOP) with topical medications in normal-tension glaucoma significantly reduced risk of progression to visual field impairment and/or optic disc damage. Original Date of Publication: July 1998 Study Rundown: Increased intraocular pressure (IOP) is known to be a significant risk factor for glaucoma. However, some patients...
1. Patients with open-angle glaucoma treated with latanoprost experienced significantly longer preservation of visual acuity and greater reduction of intraocular pressure than did patients treated with placebo eye drops. Evidence Rating Level: 1 (Excellent)      Study Rundown: Open-angle glaucoma is the leading cause of irreversible blindness worldwide and is...

Patient Basics: Glaucoma

Originally published by Harvard Health. What Is It? Glaucoma is a common eye condition in which vision is lost because of damage to the optic nerve. The optic nerve carries information about vision from the eye to the brain. In most cases, the optic nerve is damaged when the pressure of fluid...
Classics Series, Landmark Trials in Medicine
1. At 5 years, the probability of developing open-angle glaucoma was significantly lower in the group that received topical ocular hypotensive medication compared to the observed group. 2. Older age, male gender, African-American ethnicity, larger cup-to-disc ratios, higher IOP, greater visual field deficits, heart disease, and reduced cornea thickness were...
Image: PD 1. Both ß-blockers (-0.92 mmHg, p<0.001) and nitrates (-0.63 mmHg, p=0.011) were associated with a significantly lower intraocular pressure. 2. Statins and aspirin were initially associated with lower intraocular pressure, but were found to be due to concurrent use of ß-blockers. Evidence Rating Level: 2 (Good) Study Rundown: In this study,...
Image: PD 1. Outflow facility in cadaveric eyes increased from a baseline of 0.28 ± 0.10 µL/min/mmHg to 0.44 ± 0.13 µL/min/mmHg after implantation of the Hydrus microstent (p=0.001). 2. Compared to cadaveric eyes implanted with iStents, eyes implanted with the Hydrus scaffold had a significantly greater increase in outflow facility...
Image: PD  1. Moorsfield Motion Displacement Test (MMDT) had 86% sensitivity and 95% specificity in diagnosing glaucoma.  2. Probability of true damage was significantly higher among the glaucoma group (15.0%) vs. healthy subjects (0.9%; p<0.0001).  Evidence Rating Level: 2 (Good)  Study Rundown: This study identified a cheap, and rapid method of screening for...
Image: PD Human eyesight with glaucoma 1. Various concentrations of Rho kinase inhibitor K-115 decreased IOP after administration compared to placebo (p<0.05).  2. The only significant side effect was conjunctival hyperemia, which was painless and resolved within 6 hours. Evidence Rating Level: 1 (Excellent)  Study Rundown: Rho kinase inhibitors are a promising new...
Image: PD 1. Out of 5,603 West Africans interviewed, 362 (6.8%) were identified as having glaucoma. Age was found to be a significant risk factor, with 3.7% of 40-49 year olds and 14.6% of those over 80 years old affected.  2. Only 12 of the patients diagnosed with glaucoma (3.3%) were...