Tag: hepatitis

1. In patients with severe alcoholic hepatitis, treatment with prednisolone or pentoxifylline did not significantly reduce mortality at 28 days. Moreover, these treatments did not reduce mortality or the need for liver transplantation at the 90-day or 1 year timepoints. 2. Patients treated with prednisolone experienced significantly higher rates...
In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Long-Term Efficacy of a Hepatitis E Vaccine Hepatitis E virus (HEV) is most frequently a waterborne infection in resource-limited countries that can result in acute hepatitis and death especially in pregnant women....
1. A new hepatitis E vaccine tested in China was safe and provided protection from the virus for up to 4.5 years after vaccination.  Evidence Rating Level: 1 (Excellent) Study Rundown: The hepatitis E virus, endemic to Asia, Africa, the Middle East and Central America, is a waterborne virus...
Image: PD 1. Seroprotection after a challenge dose of hepatitis B (HB) vaccine was observed in 92% of adolescents (16-19 years) who had received the HB vaccine series as an infant. 2. Higher geometric mean anti-HB surface antigen antibody titers were seen after challenge with HB vaccine in adolescents whose infant...
Image: PD 1. The risk of hepatocellular carcinoma recurrence increased with high levels of hepatitis B surface antigen (HBsAg), specifically at HBsAg above 1000 IU/mL.  2. Both 5-year disease-free survival and overall survival was lower in patients with high HBsAg levels, despite low viral loads.  Evidence Rating Level: 2 (Good) Study Rundown:  Partial...
Image: PD  In this section, we will highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Pretreatment with Prasugrel in Non–ST-Segment Elevation Acute Coronary Syndromes Prasugrel, a P2Y12 receptor antagonist anti-platelet medication, has been previously shown to be effective in treating non-ST-segment elevation (NSTE) acute coronary...
Image: PD  1) Hepatitis C virus (HCV) liver transplant (LT) recipients receiving perioperative transfusions have increased fibrosis and decreased 1- and 5-year survival when compared to their non-transfused counterparts.  2) Negative impact of transfusion may be due to early immune modulation leading to suppression of HCV-specific IFN-gamma and activation of IL-17.  Evidence...
Image: PD 1. Liver failure was more frequent in post-hepatectomy patients with HBV reactivation, resulting in shorter 3-year disease-free survival and overall survival. 2. Prophylactic antiviral treatment is protective against HBV reactivation. Routine prophylactic antiviral treatment should be used for patients with hepatocellular carcinoma associated with Hepatitis B. If administered prior...