Tag: IBD

1. Anemia increased the risk of development of Crohn’s disease, inversely to hemoglobin concentration 2. Anemia was not associated with an increased risk of ulcerative colitis. Evidence Rating Level: 2 (Good) Though inflammatory bowel disease (IBD) can lead to anemia, whether anemia may be a surrogate marker for the early detection of...

Anemia is associated with the risk of Crohn’s disease, not ulcerative colitis: A nationwide population-based cohort study 1. Anemia increased the risk of development of Crohn’s disease, inversely to hemoglobin concentration 2. Anemia was not associated with an increased risk of ulcerative colitis. Evidence Rating Level: 2 (Good) Though inflammatory bowel disease (IBD)...

1. In children with chronic, non-bloody diarrhea and abdominal pain, a clinical prediction tool using symptoms, C-reactive protein (CRP), hemoglobin, and fecal calprotectin accurately predicted the presence or absence of inflammatory bowel disease (IBD). 2. This strategy may be helpful in reducing the number of unnecessary endoscopies for children with...

1. In this case-control study of patients of European ancestry with inflammatory bowel disease (IBD), variants in NUDT15 were associated with an increased risk of thiopurine-induced myelosuppression (TIM). 2. There were no sex-based differences in these genetic variants nor were there any differences based on IBD type. Evidence Rating Level: 2 (Good) Study Rundown: Thiopurine-induced...

1. In this case-control study of patients of European ancestry with inflammatory bowel disease (IBD), variants in NUDT15 were associated with an increased risk of thiopurine-induced myelosuppression (TIM). 2. There were no sex-based differences in these genetic variants nor were there any differences based on IBD type. Evidence Rating Level: 2...

1. From a retrospective single center cohort study, 29% of patients taking anti-TNF therapy for inflammatory bowel disease developed skin manifestations, most often psoriasiform eczema and eczema. 2. Of those who developed skin manifestations, 10.6% stopped therapy because of the skin lesions, and most lesions resolved upon discontinuation of therapy. Evidence...

1. Patients who took isotretinoin had a lower risk of developing inflammatory bowel disease (IBD) compared to the non-exposed group.      Evidence Rating Level: 2 (Good) Study Rundown: Isotretinoin is commonly used for the treatment of severe nodulocystic acne, secondary to an unknown mechanism that likely involves regulation of cell...

In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Loss-of-function Mutations in APOC3, Triglycerides, and Coronary Disease; Loss-of-function Mutations in APOC3 and Risk of Ischemic Vascular Disease Apolipoprotein C3, a protein in remnant cholesterol particles, is associated with hypertriglyceridemia, which has been...

1. In this cohort study, use of TNF-a inhibitors in inflammatory bowel disease patients was not associated with an increased risk of malignancy.  2. While a modest increased risk of malignancy was observed among those taking TNF-a inhibitors when compared to individuals who never took TNF-a inhibitors, there was no...

Image: PD/Colitis 1. 96% of the low dose and 95% of the high dose patients did not experience postural hypotension on postoperative day (POD) 1. 2. There were no differences in perioperative treatments required between the low and high dose steroid groups (volume of intravenous fluids, blood transfusions, etc.).  3. There were...