Tag: IBD

1. Inflammatory bowel disease (IBD) is associated with increased risk of coronary microvascular dysfunction (CMD). 2. Surgical intestinal resection in IBD patients improved coronary flow velocity reserve (CFVR), a measure of CMD. Evidence Rating Level: 2 (Good) Inflammatory bowel diseases (IBDs) include conditions such as Crohn Disease (CD) and Ulcerative Colitis (UC)....

1. From 1996 to 2011, life expectancy for IBD patients increased by approximately 3 years, whereas from 1996 to 2008, healthy life expectancy decreased in males and stayed the same in females. 2. People with IBD continue to have lower life and healthy life expectancies than individuals without IBD, ranging...

Advance care planning in patients with advanced cancer: A 6-country, cluster-randomised clinical trial 1. An advanced care planning (ACP) intervention was not found to increase quality of life compared to usual care, in patients with advanced lung or colorectal cancer. 2. ACP was found to increase the number of patients receiving...

1. Anemia increased the risk of development of Crohn’s disease, inversely to hemoglobin concentration 2. Anemia was not associated with an increased risk of ulcerative colitis. Evidence Rating Level: 2 (Good) Though inflammatory bowel disease (IBD) can lead to anemia, whether anemia may be a surrogate marker for the early detection of...

Anemia is associated with the risk of Crohn’s disease, not ulcerative colitis: A nationwide population-based cohort study 1. Anemia increased the risk of development of Crohn’s disease, inversely to hemoglobin concentration 2. Anemia was not associated with an increased risk of ulcerative colitis. Evidence Rating Level: 2 (Good) Though inflammatory bowel disease (IBD)...

1. In children with chronic, non-bloody diarrhea and abdominal pain, a clinical prediction tool using symptoms, C-reactive protein (CRP), hemoglobin, and fecal calprotectin accurately predicted the presence or absence of inflammatory bowel disease (IBD). 2. This strategy may be helpful in reducing the number of unnecessary endoscopies for children with...

1. In this case-control study of patients of European ancestry with inflammatory bowel disease (IBD), variants in NUDT15 were associated with an increased risk of thiopurine-induced myelosuppression (TIM). 2. There were no sex-based differences in these genetic variants nor were there any differences based on IBD type. Evidence Rating Level: 2 (Good) Study Rundown: Thiopurine-induced...

1. In this case-control study of patients of European ancestry with inflammatory bowel disease (IBD), variants in NUDT15 were associated with an increased risk of thiopurine-induced myelosuppression (TIM). 2. There were no sex-based differences in these genetic variants nor were there any differences based on IBD type. Evidence Rating Level: 2...

1. From a retrospective single center cohort study, 29% of patients taking anti-TNF therapy for inflammatory bowel disease developed skin manifestations, most often psoriasiform eczema and eczema. 2. Of those who developed skin manifestations, 10.6% stopped therapy because of the skin lesions, and most lesions resolved upon discontinuation of therapy. Evidence...

1. Patients who took isotretinoin had a lower risk of developing inflammatory bowel disease (IBD) compared to the non-exposed group.      Evidence Rating Level: 2 (Good) Study Rundown: Isotretinoin is commonly used for the treatment of severe nodulocystic acne, secondary to an unknown mechanism that likely involves regulation of cell...