Tag: IBD

In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Loss-of-function Mutations in APOC3, Triglycerides, and Coronary Disease; Loss-of-function Mutations in APOC3 and Risk of Ischemic Vascular Disease Apolipoprotein C3, a protein in remnant cholesterol particles, is associated with hypertriglyceridemia, which has been...
1. In this cohort study, use of TNF-a inhibitors in inflammatory bowel disease patients was not associated with an increased risk of malignancy.  2. While a modest increased risk of malignancy was observed among those taking TNF-a inhibitors when compared to individuals who never took TNF-a inhibitors, there was no...
Image: PD/Colitis 1. 96% of the low dose and 95% of the high dose patients did not experience postural hypotension on postoperative day (POD) 1. 2. There were no differences in perioperative treatments required between the low and high dose steroid groups (volume of intravenous fluids, blood transfusions, etc.).  3. There were...
Image: PD 1. The severity of Crohn’s disease as assessed by the Pediatric Crohn’s Disease Activity Index in patients recruited from 3 pediatric specialty centers decreased significantly over the course of a 12-week treatment regimen with infliximab. 2. All patients were on corticosteroids at the start of the study; however, steroid...
Image: CC/Wiki 1. After 8 weeks of treatment, thalidomide demonstrated improved rates of clinical remission as compared to placebo. 2. The mean duration of the remission induced by thalidomide was 181 weeks versus the 6 weeks noted in the placebo group. Evidence Rating Level: 1 (Excellent) Study Rundown: About a quarter of adult...
Image: PD In this section, we will highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Combined Angiotensin Inhibition for the Treatment of Diabetic Nephropathy Diabetic nephropathy is a leading cause of end-stage renal disease (ESRD).  Angiotensin-converting-enzyme (ACE) inhibitors and angiotensin II-receptor blockers (ARBs) are commonly...
Image: PD 1. No connection was found between influenza immunization and health service utilization among pediatric Irritable Bowel Disease (IBD) patients.  2. Only 25.3% of IBD patients received the vaccine during the study period despite international guidelines supporting influenza immunization.  Evidence Rating Level: 3 (Fair)  Study Rundown: IBD therapy frequently causes immunosuppression in...