Tag: intensive care

1. Patients with septic shock in the intensive care unit (ICU) undergoing mechanical ventilation receiving hydrocortisone plus fludrocortisone had a lower 90-day all-cause mortality compared to placebo treated patients. 2. The mortality rate at ICU and hospital discharge, and day 180 were significantly lower in the hydrocortisone plus fludrocortisone group,...
1. Use of balanced crystalloids (lactated Ringers or Plasma-Lyte A) was associated with a significant reduction in acute kidney injury events compared to normal saline among intensive care unit (ICU) patients. 2. Use of balanced crystalloids was also associated with lower though nonsignificant in-hospital mortality at 30-days after admission. Evidence Rating...
1. In ICU patients, prophylactic haloperidol did not improve 28-day or 90-day survival. 2. Prophylactic haloperidol also did no reduce delirium incidence, delirium-free days, duration of mechanical ventilation, nor ICU and hospital length of stay. Evidence Rating Level: 1 (Excellent) Study Rundown: Delirium manifests as waxing and waning consciousness in ill patients...
1. The study demonstrated that in critically ill pediatric patients, there was no significant difference in total number of ICU-free days up to day 28 between lower- and higher-target glucose groups. 2. The study was stopped early due to the low likelihood of benefit for patients. Evidence Rating Level: 1 (Excellent) Study...
1. The study demonstrated that acute kidney injury (AKI) is common in critically ill children and young adults, and is associated with increased mortality. 2. The majority of patients meeting the definition of AKI were missed when only the plasma creatinine criteria was used to make a diagnosis. Evidence Rating: 2...
1. No significant difference was observed in 28-day mean SOFA score or overall mortality in patients who received levosimendan vs. controls. 2. A significant increase in successful weaning from mechanical ventilation was observed in controls vs. patients who received levosimendan. Evidence Rating Level: 1 (Excellent)  Study Rundown: Septic shock is a state...
1. In a retrospective cohort study of patients receiving mechanical ventilation in an ICU who underwent overnight extubations, there was an increase in ICU and hospital mortality compared with patient extubated during the daytime. 2. Patients undergoing overnight extubations were more likely to have mechanical ventilation (MV) duration of less...
1. Based on this retrospective cohort analysis, most of the commonly used ventilator-bundles, including head-of-bed elevation, sedative infusion interruptions, spontaneous breathing trials, and thromboprophylaxis were all associated with decreased time to extubation. In addition, sedative infusion breaks and spontaneous breathing trials were associated with lower ventilator mortality. 2. Oral care...
1. Critically ill patients in the ICU with severe acute kidney injury (AKI) who were randomized to early renal replacement therapy (RRT) had essentially the same 60-day mortality rate as those whose treatment was delayed until a hard indication for renal replacement therapy arose. 2. Patients in the delayed-strategy group...
1. In this randomized controlled trial, rehabilitation therapy, over the short term, did not reduce the time to discharge in patients who suffered acute respiratory failure when compared to care as usual. 2. However, 6 months after hospitalization, many indices of respiratory motor function were significantly better in the rehabilitation...