Tag: JAK kinase

1. Patients with active ulcerative colitis who failed prior treatment achieved significantly greater remission of disease and mucosal healing compared to those treated with placebo. 2. Remission of ulcerative colitis symptoms over 1 year was significantly greater for patients who initially responded to tofacitinib and continued therapy compared to patients...
1. Baricitinib, an oral, once-daily inhibitor of JAK1 and JAK2, has shown promise in the treatment of rheumatoid arthritis (RA). 2. In this randomized controlled trial, baricitinib was superior to injectable adalimumab and placebo, in the amelioration of prespecified RA-related symptoms and radiologic outcomes after 12 weeks of follow-up. Evidence Rating...
Image: PD 1. Mutations in the colony-stimulating factor 3 receptor (CSF3R) gene were found in a majority of samples of neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (CML).  2. Different types of CSF3R mutations are associated with vulnerability to different therapeutics in vitro and potentially in vivo.   Study Rundown: Aberrant kinases...