Tag: metformin

1. Metformin was found to be safe and tolerable in survivors of pediatric brain tumors. 2. Metformin was associated with retention of memory and processing speed abilities, as well as a reduction of white matter loss. Evidence Rating Level: 1 (Excellent) It is believed that endogenous neural precursor cells (NPCs) can promote...
1. Early combination therapy with vildagliptin and metformin is associated with improved glycemic durability in the setting of newly diagnosed type 2 diabetes. Evidence Rating Level: 1 (Excellent) Early glycemic control in type 2 diabetes is associated with glycemic durability and a reduced risk of developing related complications. The early introduction...
The clinical effectiveness of sertraline in primary care and the role of depression severity and duration (PANDA): a pragmatic, double-blind, placebo-controlled randomised trial 1. Selective serotonin reuptake inhibitors (SSRIs) are not associated with significant short-term reductions in depressive symptoms in the primary care setting, but reduce short-term anxiety and improve...
1. In children with type 2 diabetes (T2DM) on metformin, those randomized to liraglutide had better glycemic control after 26 weeks compared to placebo treated patients. 2. Patients treated with liraglutide experienced more adverse events and gastrointestinal issues than placebo patients. Evidence Rating Level: 1 (Excellent)   Study Rundown: Incidence of both childhood...
1. In children with type 2 diabetes (T2DM) on metformin, those randomized to liraglutide had better glycemic control after 26 weeks compared to placebo treated patients. 2. Patients treated with liraglutide experienced more adverse events and gastrointestinal issues than placebo patients. Evidence Rating Level: 1 (Excellent)   Study Rundown: Incidence of both...
1. In this descriptive case series, 55 cases of patients with diabetes who developed Fournier gangrene while using sodium-glucose cotransporter-2 (SGLT2) inhibitors are described. 2. While neither causality nor incidence are identified in this paper, physicians prescribing SGLT2 inhibitors should be aware of the association with Fournier gangrene. Evidence Rating Level:...
1. Continued use of metformin beyond the randomized controlled trial was found to be predictive of long-term weight loss among participants who had lost at least 5 percent of their body weight during the first year of the trial. 2. The authors observed that older age and greater amount of...
1. Prepubertal obese children treated with metformin over 6 months had significantly lower BMI z scores compared to those receiving placebo. These differences were not present in pubertal children. 2. Prepubertal obese children treated with metformin over 6 months had higher qualitative insulin-sensitivity check index (QUICKI), or lower rates of...
1. Metformin use is associated with reduced all-cause mortality in patients with chronic kidney disease, congestive heart failure, or chronic liver disease with hepatic impairment. 2. In this systemic review, fewer heart failure readmissions were observed in patients with CKD or CHF that were treated with metformin. Evidence Rating Level: 1...
1. In women who had a BMI of more than 35, antenatal administration of metformin significantly reduced maternal weight gain. 2. There was no significant difference in median neonatal birth-weight between the metformin and placebo groups. Evidence Rating Level: 1 (Excellent) Study Rundown: An estimated one-third of pregnant women in the...