Tag: NSAID

1. Aspirin use before diagnosis of primary malignancy is associated with decreased risk of developing depression, anxiety and stress-related disorders post-diagnosis.  2. Use of Non-aspirin NSAIDs were associated with a higher rate of depression, anxiety, and stress-related disorders. Evidence Rating Level: 2 (Good) Inflammation appears to contribute to the development of psychiatric...

1. Ixekizumab, an IL-17 inhibitor, elicits disease response in patients with non-radiographic active axial spondyloarthritis who have failed treatment with NSAIDs. Evidence Rating Level: 1 (Excellent) Axial spondyloarthritis is a chronic inflammatory disease of the axial skeleton that is typically treated with non-steroidal anti-inflammatory drugs (NSAIDs). Biologic disease-modifying anti-rheumatic drugs (bDMARDs) have...

1. Ixekizumab, an IL-17 inhibitor, elicits disease response in patients with non-radiographic active axial spondyloarthritis who have failed treatment with NSAIDs. Evidence Rating Level: 1 (Excellent) Axial spondyloarthritis is a chronic inflammatory disease of the axial skeleton that is typically treated with non-steroidal anti-inflammatory drugs (NSAIDs). Biologic disease-modifying anti-rheumatic drugs (bDMARDs) have...

1. In this retrospective cohort analysis, patients with a history of hypertension, chronic kidney disease, or heart failure presenting to primary care physicians for musculoskeletal complaints were frequently prescribed NSAIDs. 2. Use of NSAIDs amongst high risk patients did not have any increased risk of cardiovascular or renal safety outcomes...

  Effect of Opioids vs NSAIDs and Larger vs Smaller Chest Tube Size on Pain Control and Pleurodesis Efficacy Among Patients With Malignant Pleural Effusion Thoracocentesis and subsequent pleurodesis is an effective method to control dyspnea and chest pain in patients with malignant pleural effusions. However, pain management with NSAIDs is...

1. Adding nonsteroidal anti-inflammatory drugs (NSAIDs) to concurrent antithrombotic therapy in post-myocardial infarction (MI) patients resulted in increased risk of bleeding events. 2. NSAID therapy alone was associated with an increased risk of bleeding compared to patients not receiving an NSAID. Evidence Rating Level: 2 (Good) Study Rundown: NSAIDs, such as ibuprofen...

1. In patients with atrial fibrillation, the use of non-steroidal anti-inflammatory along with antithrombotic therapy (i.e., antiplatelets or anticoagulants) was associated with increased bleeding and thromboembolic events. Evidence Rating Level: 2 (Good) Study Rundown: Atrial fibrillation (AF) is an arrhythmia that markedly increases the risk for thromboembolic stroke. To mitigate this...

Image: PD  1. Among patients with venous thromboembolism, clinically relevant bleeding and major bleeding increased with concomitant anticoagulant and NSAID use.   2. Concomitant Aspirin use also increased risk of major bleeding and clinically relevant bleeding. Evidence Rating Level: 2 (Good)  Study Rundown:  Anticoagulation is the standard of care for the treatment of...

Image: PD Primer: Non-steroidal anti-inflammatory drugs (NSAIDS) are known to be harmful in patients with myocardial infarctions. In fact, in 2007 the American Heart Association formally discouraged their use in this population subset. We also know that MI risk and the risk of death after a first MI is increased...