Tag: oncology

1. Among patients with cutaneous melanoma, ultrasound evaluation identified in half of patients in-transit metastases that were otherwise not apparent during clinical examination and changed the course of management for a third of patients. Evidence Leve Rating: 3 (Average) In-transit metastases (ITMs), or lesions that develop in lymphatics between the primary...
1. Men diagnosed with localized prostate cancer have lower self-reported quality of life outcomes, particularly sexual function in those who underwent radical prostatectomy. 2. Mental well-being was similar between men without prostate cancer and men who underwent active surveillance/watchful waiting or low dose rate brachytherapy, as their primary treatment for...
1. There was no significantly increased risk of ICU admission, intubation, or death among hospitalized patients with COVID-19 and active malignancy compared with a matched cohort of patients with COVID-19 and no malignancy. Evidence Level Rating: 2 (Good) Some institutions in the U.S. have reported higher rates of COIVD-related complications and...
1. Sarcopenia was an independent risk factor for reduced muscle mass and strength following liver resection for malignant neoplasms. Evidence Rating Level: 2 (Good) Sarcopenia is an involuntary, age-related loss of skeletal muscle mass and strength. This condition is known to drastically impact postoperative and oncological outcomes following liver resection for...
Identification of Modifiable Social and Behavioral Factors Associated With Childhood Cognitive Performance 1. Moderate increases in positive exposures were associated with improved cognitive performance in children. 2. Black children experienced fewer cognitively beneficial exposures than other racial groups. Evidence Rating Level: 2 (Good) Racial disparities in all aspects of healthcare are at least...
1. Aspirin use before diagnosis of primary malignancy is associated with decreased risk of developing depression, anxiety and stress-related disorders post-diagnosis.  2. Use of Non-aspirin NSAIDs were associated with a higher rate of depression, anxiety, and stress-related disorders. Evidence Rating Level: 2 (Good) Inflammation appears to contribute to the development of psychiatric...
Hyperthyroidism is associated with breast cancer risk and mammographic and genetic risk predictors 1. Hyperthyroidism was associated with a higher rate of breast cancer among women. 2. Risk was particularly elevated for those with toxic nodular goiter. Evidence Rating Level: 2 (Good) Breast cancer is the most common cancer among women across the...
1. Adding bevacizumab to mFOLFOX6 therapy among patients with RAS mutant metastatic colorectal cancer led to an increased rate of liver metastases resection, which has previously been demonstrated to improve survival. 2. Bevacizumab addition to standard therapy was associated with increased overall survival and progression-free survival at three years. Evidence Rating...
1. Targeted intraoperative radiotherapy for breast cancer has comparable long-term cancer-related outcomes as whole breast post-operative radiotherapy, and lower mortality from other causes. Evidence Rating Level: 1 (Excellent) Breast cancer is one of the most common cancers worldwide, with 2 million diagnoses and 626 000 deaths in 2018 alone. The treatment...
1. Unexpected weight loss, in male ever smokers aged 50 and older, meets the 3% predictive value for warranting a cancer investigation. Evidence Rating Level: 2 (Good) Unexpected weight loss (UWL) is reported in 1.5% of adults seeing a primary healthcare provider. Past studies have found associations between UWL and early...