Tag: oncology

1. In children with neutropenia and chemotherapy for cancer, 39·0°C ear temperature as a threshold for fever is non-inferior to 38·5°C for safety and appeared efficacious. Evidence Rating Level: 1 (Excellent) Febrile neutropenia is the most frequent complication of chemotherapy. Currently, the temperature limit defined for children varies across different...

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study 1. In patients with confirmed SARS-CoV-2 infection within 7 days before or 30 days after surgery, significant mortality was observed, and perioperative pulmonary complications occurred in more than half the patients. Evidence Rating: 2 (Good) Current...

Association of Sex With Outcomes in Patients Undergoing Percutaneous Coronary Intervention: A Subgroup Analysis of the GLOBAL LEADERS Randomized Clinical Trial 1. Bleeding after percutaneous coronary intervention (PCI) was more common in women, but the effect of two antiplatelet strategies on death and new Q-wave myocardial infarction following PCI did...

1. Brachytherapy following sublobar resection (BSR) had no significant association with local NSCLC recurrence compared to sublobar resection (SR) alone. 2. Three-year overall survival rates were similar between BSR and SR. Evidence rating level: 1 (Excellent) Study Rundown: Compared to lobectomy, sublobar resection for non-small-cell lung cancer (NSCLC) is associated with greater...

1. Compared to HPV negative oropharyngeal squamous cell carcinoma, HPV positive tumors are associated with increased overall survival after progression of disease. Evidence Rating Level: 2 (Good) Study Rundown: Certain strains of human papillomavirus (HPV) are associated with oropharyngeal squamous cell carcinomas (OPCs), and HPV positive tumors have significantly reduced risk...

1. In a phase I trial, ODM-201 was well tolerated up to 1800mg per day in prostate cancer patients, without reaching the maximum tolerated dose. 2. In a phase II trial, up to 33% of patients randomized to ODM-201 had a 50% or greater decrease in serum PSA at 12...

1. In men with low-risk prostate cancer undergoing active surveillance, obesity (BMI>30) was significantly associated with pathologic and therapeutic progression after the first confirmatory biopsy. Evidence Rating Level: 3 (Average) Study Rundown: Obesity has previously been associated with increased risk of advanced prostate cancer (PCa), risk of biochemical occurrence, and PCa...

Image: PD 1. Fine needle aspiration or core biopsy for the initial diagnosis of breast cancer was underused. 2. Interventions for provider-level behavior may have a more significant impact on health care quality control than broader interventions. Evidence Rating Level: 3 (Average) Study Rundown: For women with limited breast cancer who are eligible...

Image: PD 1. Elevated circulating tumor cells (CTCs) prior to or following the first round of chemotherapy for metastatic breast cancer suggested a poor prognosis. 2. Early switch to alternative chemotherapy regimens did not improve progression-free or overall survival among patients with elevated CTCs. Evidence rating level: 1 (Excellent) Study rundown: Metastatic breast...

Image: PD 1. The use of 5α-reductase inhibitors (5ARIs) was not associated with increased risk of developing high-grade or lethal prostate cancer. 2. 5ARI use was associated with a decreased incidence of low-risk and overall prostate cancer. Evidence Rating Level: 2 (Good) Study Rundown: 5ARIs have previously been associated with a decreased...