Tag: premature infants

1. Systematic review with meta-analysis shows no statistically significant difference in morbidity and mortality outcomes when comparing use of low versus high FiO2 during initial resuscitation of preterm infants (<35 weeks gestational age). 2. Subgroup analyses of data on infants <32 weeks and ≤28 weeks also showed no difference in...
Effect of Lanadelumab Compared With Placebo on Prevention of Hereditary Angioedema Attacks: A Randomized Clinical Trial Hereditary angioedema with C1 inhibitor deficiency is a rare autosomal dominant disorder characterized by C1 inhibitor deficiency (type I) or dysfunction (type II) causing dysregulated plasma kallikrein activity, and in turn, life-threatening recurrent angioedema...
Body mass index (BMI) growth curves generated with longitudinal data for preterm infants demonstrated an initial decline in BMI driven by weight, followed by a linear increase in weight that was more pronounced in the lower gestational age (GA) groups. Evidence Rating Level: 3 (Fair) Study Rundown: Surveillance of growth...
1. In this meta-analysis, there was no significant difference between lower and higher oxygen saturation targets on a primary composite of mortality or major disability at a corrected age of 18-24 months for infants born extremely preterm. 2. Lower oxygen targets were associated with increased mortality and necrotizing enterocolitis while...
1. In preterm infants followed over a 3.75-year study period, the overall prevalence of cerebral palsy (CP) decreased from 16% to 12%, the prevalence of severe CP decreased from 26% to 16%, but the prevalence of mild CP increased from 39% to 43% 2. Overall rates of moderate to...
1. Budesonide used for prevention of bronchopulmonary dysplasia in extremely preterm infants showed no difference in rate of neurodevelopmental disability at two years compared to placebo treated infants. 2. There was an increased risk of mortality at two years amongst infants receiving budesonide. Evidence Rating Level: 1 (Excellent) Study Rundown: Bronchopulmonary dysplasia...
1. The lifetime prevalence of cerebral palsy (CP) was estimated to be 10.5% for infants born extremely premature (EP, <27 weeks gestational age), with predominantly spastic type. 2. Out of all EP-born infants with CP, at least 76% had one additional neurodevelopmental comorbidity. Evidence Rating: 1 (Excellent) Study Rundown: The...
1. Executive function (EF) performance remained stable from 8 to 18 years old among the majority of children born extremely premature (EP) or with extremely low birth weight (ELBW). 2. EP and ELBW children with typical EF development outperformed children with persistent, intermittent, or late-onset deficits in all academic domains. Evidence...
1. Rates of major neurosensory disability, IQ <-2 SD, cerebral palsy (CP), blindness, and deafness were similar at 8 years among premature infants born in 3 different eras since the 1990s. 2. Academic achievement scores at age 8, including word reading, spelling, and mathematics, were lower among premature infants born...
1. Based on this prospective cohort study, use of antenatal steroids (ANS) was linked to improved mortality and neurologic outcomes, and lower rates of necrotizing enterocolitis and bronchopulmonary dysplasia in extremely premature infants. 2. Outcomes demonstrated a dose-response relationship with a complete course of ANS linked to better outcomes than...