Tag: SARS-CoV-2

1. Clinical visits for postpartum mental health illness increased in the first 9 months of the COVID-19 pandemic comparatively to pre-pandemic rates, peaking between 0 and 90 days after birth.  2. In Ontario, Canada, postpartum people living in low income neighbourhoods had less significant visit increases compared to higher income...
1. In this cohort study, multisystem inflammatory syndrome in children was a rare but serious complication associated with SARS-CoV-2 infection. 2. The findings of increased incidence among younger people and those from ethnic minority groups emphasizes a need for further identification and risk stratification for multisystem inflammatory syndrome in children. Evidence...
1. Healthcare providers were found to have higher compliance with COVID-19 preventative measures and had more positive attitudes towards their well-being compared to non healthcare workers. 2. Healthcare providers were more knowledgeable with regards to personal hygiene, personal protective equipment, and COVID-19 transmission than non health care providers. Evidence Rating Level: ...
1. Hospitalized COVID-19 patients receiving high-dose methylprednisolone followed by oral prednisone had improved clinical outcomes compared to patients receiving dexamethasone. Evidence Rating Level: 2 (Good) In June 2020, a preliminary report of a study was published comparing hospitalized COVID-19 patients receiving dexamethasone (DXM) 6 mg daily (for 10 days) to patients who...
1. A similar proportion of patients died within 28 days of randomization in both groups (high-titre convalescent plasma vs. usual care). 2. Allocation to convalescent plasma had no significant effect on the proportion of patients discharged from hospital within 28 days. Evidence Rating Level: 1 (Excellent) Study Rundown: Convalescent plasma is a...
1. A plant-derived, virus-like particle displays the SARS-CoV-2 spike glycoprotein and appears to be a promising candidate for a vaccine. 2. Adverse outcomes were mild-to-moderate, transient, and dependent on adjuvant. Evidence Rating Level: 1 (Excellent) Study Rundown: Available vaccines for COVID-19 are proving to be effective and safe. However, the demand for...
Short-Term Antibody Response After 1 Dose of BNT162b2 Vaccine in Patients Receiving Hemodialysis 1. A single dose of BNT162b2 vaccine did not elicit a humoral immune response in most people receiving hemodialysis who had no history of previous SARS-CoV-2 infection. Evidence Rating Level: 2 (Good) One of the several groups of people...
1. In-hospital mortality within 30 days of admission for COVID-19 was 48% (vs. global mortality 31.5%). 2. Increased age, underlying comorbidities and delay in admission were associated with an increased mortality rate among African patients. Evidence Rating Level: 2 (Good) Study Rundown: The COVID-19 pandemic has exposed long-standing inequities in healthcare. Critically...
1. Hospitalized COVID-19 patients receiving high-dose methylprednisolone followed by oral prednisone had improved clinical outcomes compared to patients receiving dexamethasone. Evidence Rating Level: 2 (Good) In June 2020, a preliminary report of a study was published comparing hospitalized COVID-19 patients receiving dexamethasone (DXM) 6 mg daily (for 10 days) to patients...
1. There was a vaccine efficacy of 97.2% against symptomatic COVID-19 infection in individuals at least 7 days after their second vaccine dose. 2. Substantial and consistent declines in COVID-19 incidence corresponded to greater vaccine coverage. Evidence Rating Level: 2 (Good) Study Rundown: Beyond clinical trials, there is growing evidence of the...