Tag: trauma

1. A multimodal pain regimen using generic medications reduced opiate exposure and achieved adequate pain control for adults following trauma. Evidence Level Rating: 1 (Excellent) Effective strategies that relieve acute pain without heavy reliance on opiates are needed for patients. This unblinded, randomized, comparative effectiveness trial compared two multimodal pain regimens...

An exploratory analysis of tamsulosin for Overactive Bladder (OAB) in men with varying voiding symptom burden 1. Among men with symptoms of overactive bladder with or without concomitant benign prostatic hyperplasia, tamsulosin therapy significantly reduced the symptoms of overactive bladder. Evidence Rating Level: 2 (Good) Lower urinary tract symptoms (LUTS) are common...

1. In trauma patients at risk for hemorrhage, pre-hospital administration of tranexamic acid did not significantly improve 30-day mortality compared to a placebo. 2. 30-day mortality outcomes were higher in the treatment group, when tranexamic acid was administered within 1 hour of injury, when the patient underwent severe shock, or...

1. Longer pre-hospital times for trauma patients were not associated with 30-day mortality. 2. A 10-minute delay in pre-hospital time for trauma patients was associated with a 6% increased odds of a poor functional outcome upon discharge. Evidence Rating Level: 2 (Good) Each year, trauma comprises 0.5% of deaths worldwide. Historically,...

Tranexamic Acid During Prehospital Transport in Patients at Risk for Hemorrhage After Injury: A Double-blind, Placebo-Controlled, Randomized Clinical Trial 1. In trauma patients at risk for hemorrhage, pre-hospital administration of tranexamic acid did not significantly improve 30-day mortality compared to a placebo. 2. 30-day mortality outcomes were higher in the treatment...

1. Among trauma patients aged 10 to 17, the use of low molecular weight heparin as compared with unfractionated heparin was associated with fewer episodes of venous thromboembolism as well as a reduction in mortality. Evidence Level Rating: 2 (Good) Low molecular weight heparin (LMWH) and unfractionated heparin (UFH) are the...

1. Among trauma patients aged 10 to 17, the use of low molecular weight heparin as compared with unfractionated heparin was associated with fewer episodes of venous thromboembolism as well as a reduction in mortality. Evidence Level Rating: 2 (Good) Low molecular weight heparin (LMWH) and unfractionated heparin (UFH) are the...

Timing of Oral P2Y12 Inhibitor Administration in Non-ST Elevation Acute Coronary Syndrome 1. There does not appear to be any difference in outcome between pre- and post-treatment administration of P2Y12 inhibitors among patients experiencing a non-ST elevation acute coronary syndrome with planned invasive intervention. 2. Prasugrel and ticagrelor showed similar outcomes...

1. In this randomized controlled trial, the incidence of secondary procedures within 2 years did not differ significantly between patients that received a total hip arthroplasty versus a hemiarthroplasty. 2. There was a minimal clinically significant difference in function among the total hip arthroplasty group, but also a higher incidence...

Stab wounds are managed operatively and, in select cases, non-operatively, depending on a patient’s hemodynamic stability, the anatomic location of the stabbing, and whether the patient demonstrates peritoneal signs. While some studies have demonstrated that patients with injuries associated with high mortality are more likely to achieve better survival...