Tag: venetoclax

1. In untreated chronic lymphocytic leukemia (CLL) patients with coexisting conditions, patients treated with venetoclax–obinutuzumab experienced greater progression-free survival compared to patients treated with chlorambucil–obinutuzumab. 2. Rates of adverse events in the two treatment groups were similar. Evidence Rating Level: 1 (Excellent)   Study Rundown: Many patients with CLL are elderly and have...
1. In untreated chronic lymphocytic leukemia (CLL) patients with coexisting conditions, patients treated with venetoclax–obinutuzumab experienced greater progression-free survival compared to patients treated with chlorambucil–obinutuzumab. 2. Rates of adverse events in the two treatment groups were similar. Evidence Rating Level: 1 (Excellent)   Study Rundown: Many patients with CLL are elderly and...
1. Patients with relapsed or remitting chronic lymphocytic leukemia (CLL) treated with venetoclax-rituximab had a greater 2-year progression-free survival rate compared to bendamustine-rituximab treated patients. 2. Progression-free survival rates were greater for venetoclax-rituximab patients in almost all subgroup analysis, including patients with chromosome 17p deletion. Evidence Rating Level: 1 (Excellent) Study Rundown: Curative...
  1. In this phase I trial, gradual dose escalation with selective BCL2 inhibitor, venetoclax, showed a manageable safety profile and significant antitumor activity for treatment of relapsed or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic leukemia (SLL). 2. Venetoclax was safe and active at all dose levels, with no...