• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Obstetrics

Thrombophilia-associated stillbirth risk appears limited to factor V Leiden

byDenise PongandLeah Hawkins Bressler, MD, MPH
May 1, 2016
in Obstetrics
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. Maternal factor V Leiden mutations were more common among pregnancies ending in stillbirth.

2. Fetal plasminogen activation inhibitor (PAI)-1 4G/4G polymorphism was associated with decreased odds of stillbirth.

Evidence Rating Level: 3 (Average)

Study Rundown: Stillbirth, defined as fetal demise at ≥20 weeks gestation, affects approximately 6 out of every 1000 births in the United States. Risk factors include nulliparity, advanced maternal age, obesity, and black race. There are many causes of stillbirth, including obstetric complications, placental abnormalities, fetal abnormalities, infection, and maternal hypertension and diabetes. Currently, there are no standardized protocols used to evaluate stillbirth. Previous work suggested that inherited thrombophilias are a risk factor for fetal loss such that while this association is not well defined, many clinicians pursue thrombophilia workup after stillbirth. It has been posited that hypercoagulability due to inherited thrombophilias lead to thromboses in the uteroplacental circulation, which results in placental insufficiency and later, stillbirth. In the present work, the authors assessed the relationship between maternal and fetal inherited thrombophilias and stillbirth in a population-based study. They found that stillbirth was associated only with maternal homozygous factor V Leiden mutation, which is rare. As such, findings suggest that routine assessment for heritable thrombophilias may not be appropriate in the evaluation of stillbirth.

Strengths of the study included population-based dataset and analysis of both maternal and fetal mutations. Limitations included case-control design, post-hoc analysis and incomplete data from all case and control fetuses and mothers. Additional large population-based cohort studies are needed to determine the utility of heritable thrombophilia workup after stillbirth.

Click to read the study in AJOG

Relevant Reading: Thrombophilic disorders and fetal loss: a meta-analysis

RELATED REPORTS

Ferric derisomaltose may reduce heart failure-related hospitalizations

Monofilament suture does not reduce pregnancy loss compared to braided suture for cervical cerclage

Apixaban is associated with a lower risk of gastrointestinal bleeding than other direct oral anticoagulants

In-Depth [case-control study]: This study evaluated the relationship between four heritable thrombophilia mutations and stillbirth among singleton pregnancies resulting in stillbirth (n = 620) and live birth (n = 1871). Thrombophilia marker results were available for 488 stillbirth mothers, 1342 live birth mothers, 405 stillbirth fetuses and 990 live birth fetuses. The mutations of interest were factor V Leiden, prothrombin G20210A, methylene-tetrahydrofolate reductase (MTHFR) C677T and A1298C, and PAI-1 4G/5G.

Stillbirth was associated with maternal factor V Leiden mutations (p = 0.0004), with the strongest odds in women with a homozygous mutation (OR 87.44, CI 7.88-970.92). This association did not persist when the analysis was restricted to cases where cause of death was secondary to placental disease. The PAI-1 4G/4G polymorphism in fetuses was associated with decreased odds of stillbirth (OR 0.64, CI 0.44-0.92); this relationship remained significant in the sub-analysis of stillbirths due to placental pathology (OR 0.36. CI 0.16-0.81).

Image: PD

©2015 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: factor V leidenhematologystillbirth
Previous Post

Advanced maternal age associated with obstetric pelvic floor trauma

Next Post

Despite safety standards, playground-related injury remains a concern

RelatedReports

No association found between length of storage for transfused red blood cells and patient mortality
Cardiology

Ferric derisomaltose may reduce heart failure-related hospitalizations

December 27, 2022
Late gestation antidepressant use linked to postpartum hemorrhage
Obstetrics

Monofilament suture does not reduce pregnancy loss compared to braided suture for cervical cerclage

December 13, 2022
Blood type correlates with egg reserve in infertile women
Cardiology

Apixaban is associated with a lower risk of gastrointestinal bleeding than other direct oral anticoagulants

November 17, 2022
Quick Take: Left ventricular mechanical dispersion predicts arrhythmic risk in mitral valve prolapse
Cardiology

Apixaban is superior to rivaroxaban in patients with atrial fibrillation and valvular heart disease

October 31, 2022
Next Post
Girls with familial breast cancer history are well-adjusted

Despite safety standards, playground-related injury remains a concern

Phase III trial shows survival benefit for early multiple myeloma

Triple therapy prolongs progression-free survival in Multiple Myeloma

Parent/child feeding practices associated with weight status

Self-regulation strategies linked to lower weight gain in young adults

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Aspirin thromboprophylaxis noninferior to low-molecular-weight heparin in patients with fractures
  • Catheter ablation reduces rates of persistent atrial fibrillation and atrial tachyarrhythmia
  • Deep intronic FGF14 repeat expansion associated with late-onset cerebella ataxia
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options