Prophylactic anticoagulation associated with lower in-hospital and 60-day mortality for patients hospitalized with COVID-19

1. For patients hospitalized with COVID-19, both prophylactic- and treatment-dose anticoagulation were associated with lower in-hospital mortality compared with no anticoagulation. 2. However, given that...

Ibrutinib plus Venetoclax show promising results for first-line treatment of chronic lymphocytic leukemia

Evidence Rating Level: 2 (Good)  1. Combination therapy of Ibrutinib and Venetoclax may be successful first-line treatments for patients with Chronic Lymphocytic Leukemia (CLL) who...

Vemurafenib plus rituximab associated with complete response in refractory hairy-cell leukemia

1. Vemurafenib plus rituximab treatment was associated with complete response for refractory or relapsed hairy-cell leukemia patients. 2. Post hoc analysis suggested minimal residual disease...

Novel malaria vaccine candidate (R21/MM) is safe and highly protective against malaria transmission in...

1. Vaccine efficacy at 6 months for R21/MM was 74% in group 1 and 77% in group 2. 2. R21/MM showed high malaria-specific antibody titers...

Tailored antiplatelet therapy improves outcomes in patients undergoing percutaneous coronary intervention

1. Guided selection of antiplatelet therapy reduced rates of major adverse cardiovascular event rates compared to standard therapy. 2. Guided selection strategy was beneficial for...

Poloxamer 188 not effective for acute management of vaso-occlusive episodes in patients with sickle...

1. Poloxamer 188 did not decrease parenteral opioids reliance for pain control during acute vaso-occlusive episodes in adults and children with sickle cell disease. Evidence...

Calcitonin-gene related peptide antagonist therapy associated with microvascular complications in patients with Raynaud’s Phenomenon

1. Microvascular complications were uncommon but nevertheless observed when individuals with Raynaud’s phenomenon (RP) or scleroderma were treated with Calcitonin-gene related peptide (CGRP) antagonist...

Aspirin treatment without indication in patients on direct oral anticoagulants may increase the risk...

1. In patients treated with direct oral anticoagulants (DOACs) for atrial fibrillation or venous thromboembolism (VTE), adding aspirin (ASA) was associated with increased bleeding...

Sutimlimab improved hemoglobin and patient symptoms in cold agglutinin disease

1. Sutimlimab was shown to stop hemolysis, improve hemoglobin levels, and reduce patient fatigue in patients with cold agglutinin disease. 2, Infections and gastrointestinal adverse...

Pegcetacoplan improved hemoglobin levels in eculizumab-treated paroxysmal nocturnal hemoglobinuria patients

1. Pegcetacoplan was shown to reduce the change in hemoglobin level for the treatment of paroxysmal nocturnal hemoglobinuria compared to eculizumab. 2. Patients treated with...

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