Hereditary erythrocytosis is associated with a fetal-like EPO isoform
1. This case series identified three non-coding erythropoietin (EPO) variants that significantly increased gene expression under hypoxic conditions. 2. The...
Hematology
Reduced-dose apixaban noninferior to full dose for cancer-associated thrombosis
1. Among patients with active cancer and prior venous thromboembolism (VTE), extended treatment with reduced-dose apixaban demonstrated noninferior efficacy to...
Risk of bloodstream infections with indwelling peripheral catheters increase after 3 days
1. The risk of bloodstream infections (BSIs) in individuals with indwelling peripheral intravenous catheters (PIVCs) is significantly increased after 3...
Self reported physical activity not significantly different across different severities of hemophilia
1. In this cohort of individuals with hemophilia, the physical activity levels and step count did not significantly differ between...
Adjunctive middle meningeal artery embolization superior to standard care in symptomatic chronic subdural hematomas
1. In this randomized controlled trial, middle meningeal artery embolization demonstrated a decreased risk of treatment failure in patients with...
CAR+ T-cell lymphoma linked to cilta-cel therapy in myeloma
1. This study describes two cases of malignant monoclonal T-cell lymphoproliferation following ciltacabtagene autoleucel (cilta-cel) Chimeric Antigen Receptor T-cell (CAR...
Endovascular therapy improves outcomes in vertebrobasilar stroke despite increased risk of bleeding
1. Patients in the endovascular therapy group achieved greater functional outcomes at 90 days. 2. Endovascular therapy resulted in significantly...
Increased blood–urea–nitrogen-to-albumin ratio associated with increased mortality in coronavirus disease
Association between blood–urea–nitrogen-to-albumin ratio and in-hospital mortality in patients diagnosed with coronavirus disease 2019: a retrospective cohort study 1. Increased...
Beti-cel gene therapy achieves high rates of transfusion independence in severe β-thalassemia
1. 89% of patients achieved transfusion independence with beti-cel gene therapy. 2. There were no serious adverse events or treatment-related...
Intra-arterial tenecteplase has limited use after successful endovascular recanalisation of acute posterior circulation arterial occlusion
1. In patients with acute ischemic stroke due to acute intracranial occlusions of the posterior circulation, the use of intra-arterial...