• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Cardiology

Treatment of hypertension in low-risk patients not linked with improved outcomes

byJames EnglandandAnees Daud
November 2, 2018
in Cardiology, Chronic Disease
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. In this retrospective cohort study of low-risk patients with mild hypertension, treatment of hypertension was not linked to any change in mortality or cardiovascular disease.

2. In this low-risk population, treatment of hypertension was associated with increased risk of therapy-related adverse events including hypotension, syncope, and electrolyte abnormalities.

Evidence Rating Level: 2 (Good)           

Study Rundown: Currently, the American Heart Association recommends pharmacologic treatment in high-risk patients with a blood pressure of 130/80 mm Hg or higher and for all individuals with a blood pressure of 140/90mmHg or higher regardless of risk. The benefit of treating low-risk patients with mild (sustained blood pressure of 140/90-159/99mmHg) hypertension is not clear as these patients are not frequently included in trials given the low incidence rate of major cardiovascular events. The current study is a retrospective longitudinal cohort trial of low-risk patients with mild hypertension and compared mortality, and cardiovascular outcomes between those who received antihypertensive therapy and those who did not. The study found no benefit for pharmacologic therapy in this population, but there was demonstrated harm with adverse events noted to be more common in the therapy group.

The current study provides cautionary evidence towards the drive for therapy of hypertension in low-risk patients. These patients may benefit more from careful observation and non-pharmacologic therapy prior to the initiation of medications. The main strength of the study was the large cohort size. The limitations of the study included the documented cross-over between treatment and control arms, and retrospective design.

Click to read the study, published in JAMA Internal Medicine

Relevant Reading: Effect of Intensive Versus Standard Clinic-Based Hypertension Management on Ambulatory Blood Pressure

RELATED REPORTS

Radiofrequency renal denervation produces long-lasting reductions in blood pressure

Intensive blood pressure control associated with increased cerebral blood flow in patients with hypertension – the SPRINT trial

Isometric exercise training may be more effective  at blood pressure management than high intensity interval training

In-Depth [retrospective cohort]: This is a retrospective cohort study using data from the Clinical Practice Research Datalink in England, and included participants from 1998 to 2015. Patients were included if they had mild hypertension (140/90-159/99 mmHg) and low cardiovascular disease (CVD) risk. Patients were excluded if they had a history of CVD, left ventricular hypertrophy, atrial fibrillation, diabetes, chronic kidney disease, or family history of premature heart disease. Matched control cases of patients who did not receive antihypertensive therapy was obtained using propensity score and nearest-neighbour analysis.

A total of 19,143 treated patients were matched to untreated controls with a median follow-up of 5.8 years. There was no observed differences in mortality (hazard ratio [HR], 1.02; 95%CI, 0.88-1.17) or CVD (HR, 1.09; 95%CI, 0.95-1.25). Therapy was associated with a higher risk of adverse events including hypotension (HR, 1.69; 95%CI, 1.30-2.20), syncope (HR, 1.28; 95%CI, 1.10-1.50), electrolyte abnormalities (HR, 1.72; 95%CI, 1.12-2.65), and acute kidney injury (HR, 1.37; 95%CI, 1.00-1.88).

Image: PD

©2018 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

 

Tags: blood pressure
Previous Post

Angiotensin-converting enzyme inhibitor or angiotensin receptor blocker use linked with decreased mortality after inpatient acute kidney injury.

Next Post

Quick Take: Intravenous Iron in Patients Undergoing Maintenance Hemodialysis

RelatedReports

Tenofovir disoprovil fumarate HIV prophylaxis linked with minimal kidney impact
Cardiology

Radiofrequency renal denervation produces long-lasting reductions in blood pressure

April 20, 2022
Parental nonmedical prescription opioid use linked to adolescent use
Cardiology

Intensive blood pressure control associated with increased cerebral blood flow in patients with hypertension – the SPRINT trial

March 8, 2022
UTI associated with increased risk of preeclampsia
Cardiology

Isometric exercise training may be more effective  at blood pressure management than high intensity interval training

February 1, 2022
UTI associated with increased risk of preeclampsia
Cardiology

The risk of dementia is associated with being greater at the extremes of systolic blood pressure in adults 75 or older

December 15, 2021
Next Post
Nonlinear relationship between maternal hemoglobin and infant development

Quick Take: Intravenous Iron in Patients Undergoing Maintenance Hemodialysis

E-cigarette users have greater odds of subsequent cigarette use

E-cigarette users have greater odds of subsequent cigarette use

Increased risk of subsequent melanoma after first melanoma diagnosis

Quick Take: Phase Ib/II Study of Pembrolizumab and Pegylated Interferon Alfa-2b in Advanced Melanoma

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

Get 2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • #VisualAbstract: Bimekizumab shows a favourable 2-year safety profile in patients with moderate to severe plaque psoriasis
  • Medical cannabis provides little improvement to sleep in chronic pain patients
  • Alzheimer disease in individuals with Down syndrome has similar variability in age of onset and mortality rate as autosomal dominant forms
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.