• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Cardiology

Treatment of hypertension in low-risk patients not linked with improved outcomes

byJames EnglandandAnees Daud
November 2, 2018
in Cardiology, Chronic Disease
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. In this retrospective cohort study of low-risk patients with mild hypertension, treatment of hypertension was not linked to any change in mortality or cardiovascular disease.

2. In this low-risk population, treatment of hypertension was associated with increased risk of therapy-related adverse events including hypotension, syncope, and electrolyte abnormalities.

Evidence Rating Level: 2 (Good)           

Study Rundown: Currently, the American Heart Association recommends pharmacologic treatment in high-risk patients with a blood pressure of 130/80 mm Hg or higher and for all individuals with a blood pressure of 140/90mmHg or higher regardless of risk. The benefit of treating low-risk patients with mild (sustained blood pressure of 140/90-159/99mmHg) hypertension is not clear as these patients are not frequently included in trials given the low incidence rate of major cardiovascular events. The current study is a retrospective longitudinal cohort trial of low-risk patients with mild hypertension and compared mortality, and cardiovascular outcomes between those who received antihypertensive therapy and those who did not. The study found no benefit for pharmacologic therapy in this population, but there was demonstrated harm with adverse events noted to be more common in the therapy group.

The current study provides cautionary evidence towards the drive for therapy of hypertension in low-risk patients. These patients may benefit more from careful observation and non-pharmacologic therapy prior to the initiation of medications. The main strength of the study was the large cohort size. The limitations of the study included the documented cross-over between treatment and control arms, and retrospective design.

Click to read the study, published in JAMA Internal Medicine

RELATED REPORTS

Becton Dickinson Unveils Artificial Intelligence Powered Monitor for Surgery

Blood pressure readings remain consistent in noisy and public settings

Triplet therapy of telmisartan, amlodipine, and indapamide shows superior blood pressure control in hypertension management

Relevant Reading: Effect of Intensive Versus Standard Clinic-Based Hypertension Management on Ambulatory Blood Pressure

In-Depth [retrospective cohort]: This is a retrospective cohort study using data from the Clinical Practice Research Datalink in England, and included participants from 1998 to 2015. Patients were included if they had mild hypertension (140/90-159/99 mmHg) and low cardiovascular disease (CVD) risk. Patients were excluded if they had a history of CVD, left ventricular hypertrophy, atrial fibrillation, diabetes, chronic kidney disease, or family history of premature heart disease. Matched control cases of patients who did not receive antihypertensive therapy was obtained using propensity score and nearest-neighbour analysis.

A total of 19,143 treated patients were matched to untreated controls with a median follow-up of 5.8 years. There was no observed differences in mortality (hazard ratio [HR], 1.02; 95%CI, 0.88-1.17) or CVD (HR, 1.09; 95%CI, 0.95-1.25). Therapy was associated with a higher risk of adverse events including hypotension (HR, 1.69; 95%CI, 1.30-2.20), syncope (HR, 1.28; 95%CI, 1.10-1.50), electrolyte abnormalities (HR, 1.72; 95%CI, 1.12-2.65), and acute kidney injury (HR, 1.37; 95%CI, 1.00-1.88).

Image: PD

©2018 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

 

Tags: blood pressure
Previous Post

Angiotensin-converting enzyme inhibitor or angiotensin receptor blocker use linked with decreased mortality after inpatient acute kidney injury.

Next Post

Quick Take: Intravenous Iron in Patients Undergoing Maintenance Hemodialysis

RelatedReports

Downward trend in mortality rate for antineutrophil cytoplasmic autoantibody-associated vasculitis
AI Roundup

Becton Dickinson Unveils Artificial Intelligence Powered Monitor for Surgery

May 28, 2025
UTI associated with increased risk of preeclampsia
Public Health

Blood pressure readings remain consistent in noisy and public settings

February 3, 2025
Out-of-hospital medication error rate unchanged in young children
Cardiology

Triplet therapy of telmisartan, amlodipine, and indapamide shows superior blood pressure control in hypertension management

October 31, 2024
#VisualAbstract: Home Blood Pressure Telemonitoring and Nurse Case Management Reduces Blood Pressure in Patients Post-Stroke
StudyGraphics

#VisualAbstract: Home Blood Pressure Telemonitoring and Nurse Case Management Reduces Blood Pressure in Patients Post-Stroke

July 15, 2024
Next Post
Nonlinear relationship between maternal hemoglobin and infant development

Quick Take: Intravenous Iron in Patients Undergoing Maintenance Hemodialysis

E-cigarette users have greater odds of subsequent cigarette use

E-cigarette users have greater odds of subsequent cigarette use

Increased risk of subsequent melanoma after first melanoma diagnosis

Quick Take: Phase Ib/II Study of Pembrolizumab and Pegylated Interferon Alfa-2b in Advanced Melanoma

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • SGLT2 inhibitors may delay cognitive impairment in elderly patients with heart failure
  • Nerandomilast slows decline in FVC in idiopathic pulmonary fibrosis
  • Mazdutide significantly reduces weight in adults with overweight or obesity
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.