• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Cardiology

Treatment with Percutaneous Coronary Intervention versus Coronary Artery Bypass not associated with increased rate of memory decline in older adults

byPiero CalcagnoandMichael Pratte
May 19, 2021
in Cardiology, Chronic Disease, Imaging and Intervention
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. Rate of age-related memory decline did not significantly differ when comparing individuals over the age of 65 who underwent percutaneous coronary intervention (PCI) versus coronary artery bypass grafting.

2. Coronary artery bypass grafting that involved the use of a cardiopulmonary bypass pump was associated with a greater rate of memory decline versus PCI, while bypass without pump was not.

Evidence Rating Level: 2 (Good)

Study Rundown: The mainstay of ischemic coronary artery disease treatment is currently either surgical treatment with coronary artery bypass grafting (CABG), or  non-surgical treatment with percutaneous coronary intervention (PCI). CABG treatment traditionally involves the use of a cardiopulmonary bypass machine, however due to its harmful neurological and renal side-effects, a method to perform CABG that does not involve one was developed (off-pump CABG). PCI is also purposed not to have the same possible harmful side effects as CABG that uses a bypass machine, due to PCI avoiding the use of general anesthesia and surgical trauma. It is still relatively unclear however, if these hypotheses are correct. This study was done to determine the rate of age-related memory decline in patients who were treated with PCI or CABG, and if the use of a cardiopulmonary bypass machine influences age-related memory decline. The study consisted of using 1680 participants over the age of 65 who were registered in the national health and retirement study (HRS) and have underwent either a CABG or PCI procedure. The study was divided into 1015 individuals who had a PCI performed and 665 individuals who had a CABG performed. When comparing post-treatment memory decline values between groups, the rate of memory decline between the two groups did not significantly differ from each other. However, there was a significant difference between the rate of memory loss between 168 individuals who were treated with off-pump CABG versus PCI. The study’s results are limited however, as the off-pump CABG had a relatively small sample size compared to the main cohort. The study also used a statistically significant value of 1 standard deviation, however this value has not been formally established as clinically important. The study did however perform an extensive characteristic analysis, showing the groups’ populations were similar in many variables which impact neurological function.

Click to read the study in JAMA

Click to read an accompanying editorial in JAMA

Relevant Reading: Cognitive and Cardiac Outcomes 5 Years After Off-Pump vs On-Pump Coronary Artery Bypass Graft Surgery

RELATED REPORTS

Canadian Syncope Risk Score demonstrates international external validation

Computed tomography a suitable diagnostic alternative for obstructive coronary artery disease

Treatment of rhythmic and periodic EEG patterns in comatose survivors of cardiac arrest

In-depth [Retrospective cohort]: This retrospective cohort study consisted of analyzing HRS participant data from 1992-2010 who have underwent a PCI or CABG to determine if there is a significant difference in memory loss associated with these treatments. Memory loss was assessed by using HRS memory score which was developed by calibrating core HRS cognition questionnaire items against the 1995 HRS study sample. Memory score decline was declared statistically significant if it declined by a standard deviation of 1 or 0.048 memory units/year, as 95% of cases in this study fell between -0.93 to 1.50. The study consisted of 1015 PCI participants and 665 CABG participants. Inverse probability-weighted cohort analysis showed groups were similar in BMI, smoking status, hypertension status, diabetes, depressive symptoms, pain, prior stroke, partnered status, level of education, race/ethnicity distribution, and percentage of wealth greater than cohort median. CABG group had a mean age of 74.8 years and a 65.8% male population. PCI group had a mean age of 75 years and a 54.4% male population. Memory tests were elicited 3 years prior to procedures and 5 years after procedures. Memory scores showed that the PCI experimental group had a mean age-related memory decline of 0.064 memory units (95% CI, 0.052 to 0.078) before treatment and a mean age-related memory decline of 0.060 memory units (95% CI, 0.048 to 0.071) after treatment. The CABG group had similar rates of memory decline with a mean memory decline of 0.049 memory units/year (95% CI, 0.033 to 0.065) before treatment and 0.059 memory units/year (95% CI, 0.047 to 0.072) after treatment. Subtracting the two non-rounded values yielded a memory units/year difference of less than 0.001, indicating memory loss between CABG and PCI participants occurred at approximately the same rate (p=0.98)When calculating off-pump CABG memory decline, results show an after-treatment memory decline of 0.074 memory units/year (95% CI, 0.052 to 0.096). When subtracting the highest end of the 95% confidence interval of off-pump CABG to the lowest end of the 95% confidence interval of PCI, it showed a memory unit/year of 0.046 memory units/year (95% CI, 0.008 to 0.084) which was statistically significant, as it was more than the 1 standard deviation limit. This study therefore indicates that there is no significant difference in the rate of age-related memory decline after PCI vs. CABG, but one after off-pump CABG vs. PCI.

Image: PD

©2021 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: coronary artery bypass surgery (CABG)myocardial infarction (MI)percutaneous coronary intervention (PCI)
Previous Post

#VisualAbstract: Incidence of melanoma and non-melanoma skin cancers has increased in the USA over the past three decades

Next Post

South Asian and Black populations disproportionately affected by COVID-19 in the United Kingdom  

RelatedReports

Epileptogenic foci may be lateralized using functional brain glutamate imaging
Cardiology

Canadian Syncope Risk Score demonstrates international external validation

May 13, 2022
Patient Basics: Atherosclerosis
Cardiology

Computed tomography a suitable diagnostic alternative for obstructive coronary artery disease

March 14, 2022
Patient Basics: Electroencephalogram (EEG)
Cardiology

Treatment of rhythmic and periodic EEG patterns in comatose survivors of cardiac arrest

March 2, 2022
Patient Basics: Heart Attack (Myocardial Infarction)
Cardiology

Effectiveness of sacubitril-valsartan in post-myocardial infarction management

February 3, 2022
Next Post
Novel coronavirus identified from patients with pneumonia in Wuhan, China

South Asian and Black populations disproportionately affected by COVID-19 in the United Kingdom  

#VisualAbstract: Rifapentine-moxifloxacin noninferior to standard of care treatment for pulmonary tuberculosis

#VisualAbstract: Tendon injuries associated with fluoroquinolone use in adolescents are extremely rare

2 Minute Medicine Rewind January 28, 2019

Cardiovascular safety of hydroxychloroquine in veterans with rheumatoid arthritis

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

Get 2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Alzheimer disease in individuals with Down syndrome has similar variability in age of onset and mortality rate as autosomal dominant forms
  • #VisualAbstract: Ruxolitinib shows long-term safety and efficacy in inadequately controlled polycythaemia vera without splenomegaly
  • Wellness Check: Sleep
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.