• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Cardiovascular safety of hydroxychloroquine in veterans with rheumatoid arthritis

byBrian DoughertyandAlex Chan
May 20, 2021
in Chronic Disease, Rheumatology
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. Among a large, matched cohort of veterans with rheumatoid arthritis, initiation of hydroxychloroquine was not associated with a higher risk of adverse cardiovascular events or death.

Evidence Rating Level: 1 (Excellent)

In anecdotal case reports, hydroxychloroquine (HCQ) has been reported to prolong the QT interval, thus increasing the risk of arrhythmia and sudden cardiac death. This concern had been heightened in the recent past due to the brief, and now-revoked, authorization of HCQ for the treatment of COVID-19. Because HCQ is often used in the management of patients with rhematic diseases, this study sought to evaluate the safety of HCQ among veterans with rheumatoid arthritis (RA). A strategy that attempted to emulate the design of a randomized controlled trial was utilized, though ultimately the study was of a propensity score-matched cohort design. The primary outcomes were incident long QT syndrome (LQTS), arrhythmia-related hospitalization, and all-cause mortality. 4,426 veterans with RA treated with HCQ (mean [SD] age = 63.9 [12.0] years, 13.8% female) were matched with 4,426 veterans with RA treated with a disease-modifying antirheumatic drug (DMARD) other than HCQ (mean [SD] age = 63.9 [11.9] years, 14.2% female). There were found to be 3 LQTS events and 56 arrhythmia-related hospitalizations, of which 2 and 30, respectively, belonged to the HCQ cohort. Finally, all-cause mortality occurred in 144 and 136 veterans in the HCQ and non-HCQ cohorts, respectively (HR 1.16, 95% CI 0.68 to 1.95). In all, initiation of HCQ for the treatment of RA was found to be safe and not associated with increased all-cause mortality. Furthermore, this study demonstrates that the incidence of LQTS is extremely low, and not heightened by administration of HCQ, at least in this particular cohort.

Click to read the study in A&R

Image: PD

©2021 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

RELATED REPORTS

Upadacitinib with glucocorticoids superior to glucocorticoids alone for giant cell arteritis remission

Obinutuzumab plus standard therapy is efficacious in managing active lupus nephritis

Inebilizumab reduces the risk of flares in IgG4-related disease

Tags: arthritisrheumatoid arthritisrheumatology
Previous Post

#VisualAbstract: Tendon injuries associated with fluoroquinolone use in adolescents are extremely rare

Next Post

#VisualAbstract: Hyperfractionated radiotherapy with concomitant chemotherapy is highly effective for locally advanced head and neck cancers

RelatedReports

Study explores effects of daily iron supplementation in 2- to 5-year-olds
Chronic Disease

Upadacitinib with glucocorticoids superior to glucocorticoids alone for giant cell arteritis remission

June 9, 2025
Multidrug induction therapy increases remission from lupus nephritis
Chronic Disease

Obinutuzumab plus standard therapy is efficacious in managing active lupus nephritis

May 21, 2025
Chronic Disease

Inebilizumab reduces the risk of flares in IgG4-related disease

April 8, 2025
dermatomyositis
Chronic Disease

Dazukibart is effective in reducing disease activity in adults with refractory dermatomyositis

February 12, 2025
Next Post
#VisualAbstract: Hyperfractionated radiotherapy with concomitant chemotherapy is highly effective for locally advanced head and neck cancers

#VisualAbstract: Hyperfractionated radiotherapy with concomitant chemotherapy is highly effective for locally advanced head and neck cancers

Sleep duration inversely related to childhood type 2 diabetes risk makers

Combined cagrilintide and semaglutide for weight management well-tolerated in early clinical trials

#VisualAbstract Phase 1 trial shows loncastuximab tesirine demonstrated significant response rates and an acceptable safety profile in patients with relapsed/refractory B-cell non-Hodgkin lymphoma

#VisualAbstract Phase 1 trial shows loncastuximab tesirine demonstrated significant response rates and an acceptable safety profile in patients with relapsed/refractory B-cell non-Hodgkin lymphoma

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Early acetaminophen use reduces mortality risk in patients with sepsis-associated encephalopathy
  • Structured Exercise after Adjuvant Chemotherapy for Colon Cancer
  • 2 Minute Medicine Rewind June 30, 2025
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.