Tag: rheumatology

Effectiveness and safety of non-steroidal anti-inflammatory drugs and opioid treatment for knee and hip osteoarthritis: Network meta-analysis 1. Topical diclofenac 70-81 mg/day was recommended as first-line pharmacological treatment for knee osteoarthritis. 2. Etoricoxib 60 mg/day and diclofenac 150 mg/day were the most effective oral NSAIDs for pain and function in OA...

1. Among a large, matched cohort of veterans with rheumatoid arthritis, initiation of hydroxychloroquine was not associated with a higher risk of adverse cardiovascular events or death. Evidence Rating Level: 1 (Excellent) In anecdotal case reports, hydroxychloroquine (HCQ) has been reported to prolong the QT interval, thus increasing the risk of...

Cardiovascular safety of hydroxychloroquine in veterans with rheumatoid arthritis 1. Among a large, matched cohort of veterans with rheumatoid arthritis, initiation of hydroxychloroquine was not associated with a higher risk of adverse cardiovascular events or death. Evidence Rating Level: 1 (Excellent) In anecdotal case reports, hydroxychloroquine (HCQ) has been reported to prolong...

1. At 12 weeks, the proportion of patients with an IGA score of 0 or 1 was significantly greater in the sonelokimab groups than in the placebo group. 2. No dose-response associations with toxicity were apparent for the sonelokimab groups. Evidence Rating Level: 1 (Excellent)  Study Rundown: Sonelokimab is a novel trivalent...

1. Among a cohort of patients with knee osteoarthritis, a web-based intervention of self-directed strengthening exercises and activity guidance supported with automated text messaging improved both pain and functional capacity at 24 weeks. Evidence Rating Level: 1 (Excellent) Osteoarthritis (OA) of the knee is highly prevalent and has no known cure;...

Effects of a self-directed web-based strengthening exercise and physical activity program supported by automated text messages for people with knee osteoarthritis: A randomized clinical trial 1. Among a cohort of patients with knee osteoarthritis, a web-based intervention of self-directed strengthening exercises and activity guidance supported with automated text messaging improved...

1. For the treatment of ANCA-associated vasculitis, avacopan was non-inferior to prednisone taper for the number of remissions at week 26. 2. Avacopan was superior to prednisone taper for sustained remission at week 52. Evidence Rating Level: 1 (Excellent) Study Rundown: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a life-threatening vasculitis. The current...

1. Among patients categorized as B-cell poor group via RNA sequencing, tocilizumab had a significantly higher response rate than rituximab. 2. Likelihood of adverse events and serious adverse events were comparable between both treatment groups. Evidence Rating Level: 1 (Excellent) Study Rundown: Rheumatoid arthritis is a chronic autoimmune condition with considerable morbidity...

1. There were no significant differences in symptom duration, length of hospital stay, and chest X-ray score between patients hospitalized for COVID-19 pneumonia with rheumatic and musculoskeletal diseases, compared to controls without these comorbidities. 2. Major risk factors for hospital admission and mortality included older age and pre-existing comorbidities (i.e....

1. In a posthoc analysis of 2, phase 3 randomized controlled trials of over 1000 patients with moderate-to-severe plaque psoriasis, tofacitinib (an oral Janus kinase inhibitor) treatment demonstrated significantly improved clinical nail psoriasis severity scores at 16 weeks compared to placebo. Evidence Rating Level: 1 (Excellent) Study Rundown: Psoriasis is a...