• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home StudyGraphics

#VisualAbstact: Association Between Tumor Necrosis Factor Inhibitor Exposure and Inflammatory Central Nervous System Events

byConstance Wu
July 3, 2020
in StudyGraphics
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

RELATED REPORTS

Initiation of targeted disease-modifying antirheumatic drugs in patients with rheumatoid arthritis not associated with reduced risk of Alzheimer disease and related dementia

#VisualAbstract: IL-17 inhibitors are associated with higher treatment persistence than TNF inhibitors in patients with psoriasis and psoriatic arthritis

Tofacitinib increases cardiovascular and cancer risk in rheumatoid arthritis

1. Tumor necrosis factor inhibitor exposure in patients with autoimmune disease, particularly rheumatoid arthritis, was associated with increased risk of inflammatory central nervous system events.

Evidence Rating Level: 2 (Good)

The U.S. Food and Drug Administration has approved five tumor necrosis factor (TNF) inhibitors as immunotherapies for autoimmune diseases: etanercept, adalimumab, infliximab, golimumab, and certolizumab pegol. However, TNF inhibitor exposure has since been found to potentially be associated with inflammatory, demyelinating events in the central nervous system (CNS) including but not limited to multiple sclerosis and optic neuritis. This nested case-control study investigated TNF inhibitors (type, cumulative exposure duration, time of exposure) and subsequent risk of demyelinating (n = 56) and nondemyelinating CNS events (n = 50) in individuals with autoimmune disease. Participants with autoimmune disease were selected via the Mayo Clinic electronic medical record system across three sites. Between 2003 and 2019. The control group (no CNS events) was selected from the same system and matched 1:1 for sex, birth year, and autoimmune disease (n = 106). Participants were excluded if any inflammatory CNS events occurred prior to the development of an autoimmune disease. Thus, a total of 212 participants were included in this study (median [IQR] age at disease onset = 52 [43-62] years, 64% female). A total of 48 participants with inflammatory demyelinating CNS events had multiple sclerosis, optic neuritis, transverse myelitis, or neuromyelitis optica spectrum disorder (NMOSD). Common demyelinating CNS events were meningitis, idiopathic leptomeningitis, idiopathic pachymeningitis, idiopathic meningoencephalitis, autoimmune encephalitis, neurosarcoidosis, and CNS vasculitis. The experimental group was more likely to experience TNF inhibitor exposure (difference 20%), suggesting an association with increased risk of inflammatory CNS events (adjusted OR 3.01, 95% CI 1.55 to 5.82, p = 0.001). Upon stratification by nondemyelinating and demyelinating events, results remained similar. Further analyses suggested a primary association among those with rheumatoid arthritis (adjusted OR 4.82, 95% CI 1.62 to 14.36, p = 0.005). Overall, this study supports the hypothesis that TNF exposure is associated with increased odds of inflammatory CNS events in individuals with autoimmune disease. Further research is warranted to determine when this increased risk is introduced and how to improve these outcomes.

Click to read the study in JAMA Neurology

©2020 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: inflammatory diseaserheumatoid arthritisTNF inhibitortumor necrosis factor (TNF)
Previous Post

Healthy lifestyle for prevention of premature death among users and nonusers of common preventive medications

Next Post

Physical exercise associated with reduced risk of chronic pain in University students

RelatedReports

Quick Take: The clinical effectiveness of sertraline in primary care and the role of depression severity and duration (PANDA): a pragmatic, double-blind, placebo-controlled randomized trial
Neurology

Initiation of targeted disease-modifying antirheumatic drugs in patients with rheumatoid arthritis not associated with reduced risk of Alzheimer disease and related dementia

April 13, 2022
#VisualAbstract: IL-17 inhibitors are associated with higher treatment persistence than TNF inhibitors in patients with psoriasis and psoriatic arthritis
StudyGraphics

#VisualAbstract: IL-17 inhibitors are associated with higher treatment persistence than TNF inhibitors in patients with psoriasis and psoriatic arthritis

April 7, 2022
2 Minute Medicine Rewind January 28, 2019
Cardiology

Tofacitinib increases cardiovascular and cancer risk in rheumatoid arthritis

February 2, 2022
#VisualAbstract: Patients report high satisfaction rates with clinic-based hidradenitis suppurativa surgery
StudyGraphics

#VisualAbstract: Patients report high satisfaction rates with clinic-based hidradenitis suppurativa surgery

January 14, 2022
Next Post
Unenhanced magnetic resonance imaging highly sensitive and specific for acute appendicitis

Physical exercise associated with reduced risk of chronic pain in University students

Lefamulin noninferior to moxifloxacin for community-acquired pneumonia

Amoxicillin for the treatment of pneumonia with tachypnea in low resource settings

#VisualAbstact: Lower LDL associated with regression of pre-existing atherosclerotic lesions but not carotid plaque incidence

#VisualAbstact: Lower LDL associated with regression of pre-existing atherosclerotic lesions but not carotid plaque incidence

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Vitamin and mineral supplementation associated with minimal to no benefit in the primary preventing of cardiovascular disease and cancer – US Preventative Services Task Force
  • RSVpreF vaccine prevents symptomatic respiratory syncytial virus infection
  • Incidence of Kawasaki disease found to be lower during the COVID-19 pandemic in the United States
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.